Koksharova Ekaterina, Ustyuzhanin Dmitry, Philippov Yury, Mayorov Alexander, Shestakova Marina, Shariya Merab, Ternovoy Sergey, Dedov Ivan
1 Endocrinology Research Centre , Moscow, Russia .
2 Cardiology Research Center , Moscow, Russia .
Diabetes Technol Ther. 2017 Feb;19(2):96-102. doi: 10.1089/dia.2016.0360.
The evaluation of brown adipose tissue (BAT) and its role in metabolism and obesity remains an important topic in the recent literature. This study evaluated the influence of the BAT triglyceride content measured by proton magnetic resonance (MR) spectroscopy in patients with type 2 diabetes mellitus (DM2) and prediabetes on insulin sensitivity.
A total of 25 patients with DM2 and prediabetes (45.9 ± 10.1 years old, body mass index [BMI] of 31.6 ± 5.4 kg/m) underwent anthropometric measurements (BMI), insulin sensitivity analysis (M value during euglycemic hyperinsulinemic clamp and homeostasis model assessment of insulin resistance), proton MR spectroscopy, and blood tests (total cholesterol, low-density lipoproteins, high-density lipoproteins, and triglycerides). The relationship between the triglyceride content in the supraclavicular fat depot and insulin sensitivity, anthropometric measurements, and blood test results was assessed.
The triglyceride content in the supraclavicular fat depot varied between 79.2% and 97.1% (mean: 92.6% ± 4.2%). The triglyceride content in the subcutaneous white adipose tissue of the neck was significantly higher (85.3%-99.3%; mean: 95.5% ± 2.9%; P = 0.0007). The triglyceride content in the supraclavicular fat depot exhibited a significantly moderate correlation with the BMI (r = 0.64; P = 0.0009). A significant weak negative correlation between the supraclavicular fat content and M value was revealed (r = -0.44; P = 0.002). Patients with high insulin resistance (IR) had a higher triglyceride content in the supraclavicular fat depot than patients with normal and lower IR (94.3% ± 2.0% vs. 90.4% ± 5.2%; P = 0.02).
Reducing the BAT content in the supraclavicular fat depot can influence the development of IR in patients with DM2 and prediabetes.
棕色脂肪组织（BAT）的评估及其在代谢和肥胖中的作用仍是近期文献中的一个重要课题。本研究评估了通过质子磁共振（MR）波谱测量的BAT甘油三酯含量对2型糖尿病（DM2）和糖尿病前期患者胰岛素敏感性的影响。
共有25例DM2和糖尿病前期患者（年龄45.9±10.1岁，体重指数[BMI]为31.6±5.4kg/m）接受了人体测量（BMI）、胰岛素敏感性分析（正常血糖高胰岛素钳夹期间的M值和胰岛素抵抗的稳态模型评估）、质子MR波谱分析和血液检查（总胆固醇、低密度脂蛋白、高密度脂蛋白和甘油三酯）。评估了锁骨上脂肪库中甘油三酯含量与胰岛素敏感性、人体测量和血液检查结果之间的关系。
锁骨上脂肪库中的甘油三酯含量在79.2%至97.1%之间变化（平均值：92.6%±4.2%）。颈部皮下白色脂肪组织中的甘油三酯含量显著更高（85.3%-99.3%；平均值：95.5%±2.9%；P=0.0007）。锁骨上脂肪库中的甘油三酯含量与BMI呈显著中度相关（r=0.64；P=0.0009）。锁骨上脂肪含量与M值之间存在显著弱负相关（r=-0.44；P=0.002）。高胰岛素抵抗（IR）患者锁骨上脂肪库中的甘油三酯含量高于正常和低IR患者（94.3%±2.0%对90.4%±5.2%；P=0.02）。
降低锁骨上脂肪库中的BAT含量可影响DM2和糖尿病前期患者IR的发展。
