Du Plessis J L, Van Gas L, Olivier J A, Bezuidenhout J D
Veterinary Research Institute, Onderstepoort.
Onderstepoort J Vet Res. 1989 Sep;56(3):195-201.
Ten stocks of Cowdria ruminantium (Ball 3, Breed, Comoro, Germishuys, Kümm, Kwanyanga, Mali, Mara, Nonile and Welgevonden) were compared from a cross-immunity, serological and mouse pathogenicity point of view. They were found to differ in varying degrees. Except for the Ball 3, Comoro and Germishuys stocks that were similar but not identical, there was no pattern in the antigenic diversity of the 10 stocks. The Welgevonden stock emerged as the stock that elicits an immunity against most of the South African stocks. The inability of the reference Ball 3 stock to protect sheep against no fewer than 6 other stocks questions the advisability of retaining this stock as the vaccine stock. The antigenic diversity of the 10 stocks could not be correlated with the antibody levels detected with the indirect fluorescent antibody test, since the sera against all 10 stocks reacted positively to the Kümm stock antigen and the variation in titres was not stock-related.
从交叉免疫、血清学和小鼠致病性的角度对10株反刍兽考德里氏体（Ball 3、Breed、科摩罗、Germishuys、Kümm、夸扬加、马里、马拉、诺尼勒和韦尔格冯登）进行了比较。发现它们存在不同程度的差异。除了相似但不完全相同的Ball 3、科摩罗和Germishuys株外，这10株的抗原多样性没有规律。韦尔格冯登株成为能诱导针对大多数南非毒株产生免疫力的毒株。作为参考的Ball 3株无法保护绵羊抵御不少于6种其他毒株，这让人质疑将该毒株保留为疫苗毒株是否明智。这10株的抗原多样性与间接荧光抗体试验检测到的抗体水平无关，因为针对所有10株的血清对Kümm株抗原均呈阳性反应，且滴度变化与毒株无关。
