Brunet Anne, Rando Thomas A
Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Glenn Center for the Biology of Aging, Stanford University, USA.
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Glenn Center for the Biology of Aging, Stanford University, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
Curr Opin Cell Biol. 2017 Apr;45:1-7. doi: 10.1016/j.ceb.2016.12.009. Epub 2017 Jan 24.
Aging is accompanied by a decline in tissue function, regeneration, and repair. A large part of this decline is caused by the deterioration of tissue stem cell function. Understanding the mechanisms that drive stem cell aging and how to counteract them is a critical step for enhancing tissue repair and maintenance during aging. Emerging evidence indicates that epigenetic modifiers and metabolism regulators interact to impact lifespan, suggesting that this mechanism may also affect stem cell function with age. This review focuses on the interaction between chromatin and metabolism in the regulation of tissue stem cells during aging. We also discuss how these mechanisms integrate environmental stimuli such as nutrient stress to regulate stem cell function. Finally, this review examines new perspectives for regeneration, rejuvenation, and treatment of age-related decline of stem cell function.
衰老伴随着组织功能、再生和修复能力的下降。这种下降很大程度上是由组织干细胞功能的衰退所导致的。了解驱动干细胞衰老的机制以及如何对抗这些机制，是增强衰老过程中组织修复和维持能力的关键一步。新出现的证据表明，表观遗传修饰因子和代谢调节因子相互作用以影响寿命，这表明该机制可能也会随着年龄增长影响干细胞功能。本综述重点关注衰老过程中染色质与代谢在组织干细胞调控中的相互作用。我们还讨论了这些机制如何整合营养应激等环境刺激来调节干细胞功能。最后，本综述探讨了干细胞功能与年龄相关衰退的再生、恢复活力及治疗方面的新观点。
