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从厩螫蝇（双翅目）心侧体中分离出的具有脂肪动和低海藻糖血活性的两种神经肽激素的一级结构

Primary structure of two neuropeptide hormones with adipokinetic and hypotrehalosemic activity isolated from the corpora cardiaca of horse flies (Diptera).

作者信息

Jaffe H, Raina A K, Riley C T, Fraser B A, Nachman R J, Vogel V W, Zhang Y S, Hayes D K

机构信息

Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD 20705.

出版信息

Proc Natl Acad Sci U S A. 1989 Oct;86(20):8161-4. doi: 10.1073/pnas.86.20.8161.

DOI:10.1073/pnas.86.20.8161
PMID:2813385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC298235/
Abstract

The primary structures of two neuropeptides, Tabanus atratus adipokinetic hormone (Taa-AKH) and Tabanus atratus hypotrehalosemic hormone (Taa-HoTH), from the corpora cardiaca of horse flies (Diptera: Tabanidae) have been determined. Amino acid sequences of Taa-AKH (less than Glu-Leu-Thr-Phe-Thr-Pro-Gly-Trp-NH2) and Taa-HoTH (less than Glu-Leu-Thr-Phe-Thr-Pro-Gly-Trp-Gly-Tyr-NH2) (where less than Glu = pyroglutamic acid) were determined by automated gas-phase Edman degradation of the peptides deblocked by pyroglutamate aminopeptidase and by fast atom bombardment mass spectrometry. The hormones were synthesized, and the natural and synthetic peptides exhibited identical chromatographic, spectroscopic, and biological properties. When assayed in adult face fly males, Taa-AKH and Taa-HoTH demonstrated hyperlipemic activity, in addition, Taa-HoTH also demonstrated a significant hypotrehalosemic activity.

摘要

已确定了来自牛虻（双翅目：虻科）心侧体的两种神经肽，即牛虻促脂肪动激素（Taa-AKH）和牛虻低海藻糖血激素（Taa-HoTH）的一级结构。通过对经焦谷氨酸氨肽酶去封闭的肽进行自动气相埃德曼降解以及快速原子轰击质谱法，确定了Taa-AKH（小于Glu-Leu-Thr-Phe-Thr-Pro-Gly-Trp-NH2）和Taa-HoTH（小于Glu-Leu-Thr-Phe-Thr-Pro-Gly-Trp-Gly-Tyr-NH2）（其中小于Glu = 焦谷氨酸）的氨基酸序列。对这些激素进行了合成，天然肽和合成肽表现出相同的色谱、光谱和生物学特性。在成年厩螫蝇雄性中进行测定时，Taa-AKH和Taa-HoTH表现出高脂血活性，此外，Taa-HoTH还表现出显著的低海藻糖血活性。

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