Zhao Long-Gang, Li Hong-Lan, Sun Jiang-Wei, Yang Yang, Ma Xiao, Shu Xiao-Ou, Zheng Wei, Xiang Yong-Bing
SKLORG & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, USA.
J Epidemiol. 2017 Jan;27(1):36-41. doi: 10.1016/j.je.2016.08.004. Epub 2016 Oct 18.
Green tea is one of the most widely consumed beverages in Asia. While a possible protective role of green tea against various chronic diseases has been suggested in experimental studies, evidence from human studies remains controversial.
We conducted this study using data from Shanghai Men's Health Study (SMHS) and Shanghai Women's Health Study (SWHS), two population-based prospective cohorts of middle-aged and elderly Chinese adults in urban Shanghai, China. Hazard ratios (HR) and 95% confidence intervals (CI) for risk of all-cause and cause-specific mortality associated with green tea intake were estimated using Cox proportional hazards regression models.
During a median follow-up of 8.3 and 14.2 years for men and women, respectively, 6517 (2741 men and 3776 women) deaths were documented. We found that green tea consumption was inversely associated with risk of all-cause mortality (HR 0.95; 95% CI, 0.90-1.01), particularly among never-smokers (HR 0.89; 95% CI, 0.82-0.96). The inverse association with cardiovascular disease (CVD) mortality (HR 0.86; 95% CI, 0.77-0.97) was slightly stronger than that with all-cause mortality. No significant association was observed between green tea intake and cancer mortality (HR 1.01; 95% CI, 0.93-1.10).
Green tea consumption may be inversely associated with risk of all-cause and CVD mortality in middle-aged and elderly Chinese adults, especially among never smokers.
绿茶是亚洲消费最为广泛的饮品之一。虽然实验研究表明绿茶可能对多种慢性疾病具有保护作用，但来自人体研究的证据仍存在争议。
我们利用上海男性健康研究（SMHS）和上海女性健康研究（SWHS）的数据开展了本研究，这两项研究是基于中国上海市区中年及老年成年人的前瞻性队列研究。使用Cox比例风险回归模型估计与绿茶摄入量相关的全因死亡率和特定病因死亡率的风险比（HR）及95%置信区间（CI）。
男性和女性的中位随访时间分别为8.3年和14.2年，共记录到6517例死亡（男性2741例，女性3776例）。我们发现，饮用绿茶与全因死亡率风险呈负相关（HR 0.95；95% CI，0.90 - 1.01），在从不吸烟者中尤为明显（HR 0.89；95% CI，0.82 - 0.96）。与心血管疾病（CVD）死亡率的负相关（HR 0.86；95% CI，0.77 - 0.97）略强于与全因死亡率的负相关。未观察到绿茶摄入量与癌症死亡率之间存在显著关联（HR 1.01；95% CI，0.93 - 1.10）。
饮用绿茶可能与中国中年及老年成年人的全因死亡率和CVD死亡率风险呈负相关，尤其是在从不吸烟者中。
