Ilinčić Branislava, Stokić Edita, Stošić Zoran, Kojić Nevena Eremić, Katsiki Niki, Mikhailidis Dimitri P, Isenovic Esma R
Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece.
Arch Med Sci. 2017 Feb 1;13(1):53-60. doi: 10.5114/aoms.2016.61812. Epub 2016 Aug 16.
Obesity and inadequate vitamin D status are associated with endothelial dysfunction and cardiovascular disease. We evaluated the associations between vitamin D status (i.e. serum levels of 25-hydroxyvitamin D (25(OH)D)), biomarkers of endothelial dysfunction (i.e. serum concentrations of soluble intercellular adhesion molecule 1 (sICAM-1) and soluble E-selectin (sE-selectin)), inflammatory markers (i.e. high-sensitivity C-reactive protein (hsCRP) and fibrinogen) and cardiometabolic risk factors.
Fifty obese (body mass index (BMI) ≥ 30 kg/m) non-diabetic adults (mean age: 36.2 ±5.4 years) without pre-existing cardiovascular abnormalities and 25 clinically healthy, normal weight and age-matched individuals were included. Anthropometric parameters, markers of glucose and lipid metabolism, and serum levels of inflammatory and endothelial dysfunction biomarkers were assessed in all subjects.
The mean serum 25(OH)D level was significantly lower in the obese group than in controls (33.5 ±15.2 vs. 60.1 ±23.1 nmol/l; < 0.001). In the obese group, sE-selectin (36.4 (32.1-47.2) vs. 32.4 (24.6-35.5) ng/ml, < 0.05) and hsCRP (6.0 ±3.4 vs. 3.5 ±1.0 mg/l, < 0.05) were significantly higher in individuals with lower than median vitamin D levels (i.e. 31 nmol/l) compared with those with higher vitamin D levels. In multivariable linear regression analysis, hsCRP (β = -0.43; < 0.001) and sE-selectin (β = -0.30; = 0.03) were independently and significantly associated with serum 25(OH)D levels in the obese group.
Vitamin D levels may be related to increased levels of biomarkers of endothelial dysfunction and inflammation in obese non-diabetic individuals.
肥胖和维生素D水平不足与内皮功能障碍及心血管疾病相关。我们评估了维生素D状态（即血清25-羟基维生素D（25(OH)D）水平）、内皮功能障碍生物标志物（即可溶性细胞间黏附分子1（sICAM-1）和可溶性E-选择素（sE-选择素）的血清浓度）、炎症标志物（即高敏C反应蛋白（hsCRP）和纤维蛋白原）与心脏代谢危险因素之间的关联。
纳入50名肥胖（体重指数（BMI）≥30 kg/m）且无心血管异常病史的非糖尿病成年人（平均年龄：36.2±5.4岁）以及25名临床健康、体重正常且年龄匹配的个体。对所有受试者评估人体测量参数、糖脂代谢标志物以及炎症和内皮功能障碍生物标志物的血清水平。
肥胖组的平均血清25(OH)D水平显著低于对照组（33.5±15.2 vs. 60.1±23.1 nmol/l；P<0.001）。在肥胖组中，维生素D水平低于中位数（即31 nmol/l）的个体，其sE-选择素水平（36.4（32.1 - 47.2）vs. 32.4（24.6 - 35.5）ng/ml，P<0.05）和hsCRP水平（6.0±3.4 vs. 3.5±1.0 mg/l，P<0.05）显著高于维生素D水平较高的个体。在多变量线性回归分析中，hsCRP（β = -0.43；P<0.001）和sE-选择素（β = -0.30；P = 0.03）与肥胖组血清25(OH)D水平独立且显著相关。
在肥胖非糖尿病个体中，维生素D水平可能与内皮功能障碍和炎症生物标志物水平升高有关。
