从皱叶蔷薇的花蕾中分离得到细胞毒的环氧色烯并色原酮和类黄酮。

Cytotoxic oxepinochromenone and flavonoids from the flower buds of Rosa rugosa.

机构信息

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities , Kunming 650031, Yunnan, People's Republic of China.

出版信息

J Nat Prod. 2013 Oct 25;76(10):1866-71. doi: 10.1021/np4004068. Epub 2013 Sep 24.

DOI:10.1021/np4004068

PMID:24063567

Abstract

A new oxepinochromenone, rugosachromenone A (1), seven new flavonoids, rugosaflavonoids A-G (2-8), and 11 known compounds (9-19) were isolated from the flower buds of Rosa rugosa. Compound 1 is found from Nature for the first time. Compound 2 displayed cytotoxicity against NB4, SHSY5Y, and MCF7 cells with IC50 values of 2.2, 2.5, and 2.3 μM, respectively, and 3 was toxic to A549 and MCF7 cells with IC50 values of 1.2 and 2.8 μM, respectively.

摘要

从玫瑰(Rosa rugosa)花蕾中分离得到一个新的氧杂色满酮类化合物 rugosachromenone A (1)、七个新的类黄酮化合物 rugosaflavonoids A-G (2-8) 和 11 个已知化合物 (9-19)。化合物 1 为首次从自然界中发现。化合物 2 对 NB4、SHSY5Y 和 MCF7 细胞表现出细胞毒性，IC50 值分别为 2.2、2.5 和 2.3 μM，而化合物 3 对 A549 和 MCF7 细胞具有毒性，IC50 值分别为 1.2 和 2.8 μM。