Department of Public Health, Hyogo College of Medicine, Nishinomiya, Japan.
Center for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Japan.
Indoor Air. 2017 Sep;27(5):955-964. doi: 10.1111/ina.12370. Epub 2017 Feb 27.
Endotoxins are an important biological component of particulate matter and have been associated with adverse effects on human health. There have been some recent studies on airborne endotoxin concentrations. We collected fine (PM ) and coarse (PM ) particulate matter twice on weekdays and weekends each for 48 hour, inside and outside 55 homes in an urban city in Japan. Endotoxin concentrations in both fractions were measured using the kinetic Limulus Amebocyte Lysate assay. The relationships between endotoxin concentrations and household characteristics were evaluated for each fraction. Both indoor and outdoor endotoxin concentrations were higher in PM than in PM . In both PM and PM , indoor endotoxin concentrations were higher than outdoor concentrations, and the indoor endotoxin concentrations significantly correlated with outdoor concentrations in each fraction (R =0.458 and 0.198, respectively). Indoor endotoxin concentrations in PM were significantly higher in homes with tatami or carpet flooring and in homes with pets, and lower in homes that used air purifiers. Indoor endotoxin concentrations in PM were significantly higher in homes with two or more children and homes with tatami or carpet flooring. These results showed that the indoor endotoxin concentrations were associated with the household characteristics in addition to outdoor endotoxin concentrations.
内毒素是颗粒物的重要生物组成部分，与人类健康的不良影响有关。最近有一些关于空气中内毒素浓度的研究。我们在日本一个城市的 55 户家庭内外，每个工作日和周末各采集两次细颗粒物（PM ）和粗颗粒物（PM ），持续 48 小时。使用动态鲎变形细胞溶解物检测法（kinetic Limulus Amebocyte Lysate assay）测量两个分数的内毒素浓度。评估了每个分数的内毒素浓度与家庭特征之间的关系。PM 中的内毒素浓度无论是室内还是室外都高于 PM 。在 PM 和 PM 中，室内内毒素浓度均高于室外浓度，且每个分数的室内内毒素浓度与室外浓度呈显著相关（分别为 R =0.458 和 0.198）。PM 中的室内内毒素浓度在有榻榻米或地毯地板的家庭以及有宠物的家庭中显著较高，而在使用空气净化器的家庭中则较低。PM 中的室内内毒素浓度在有两个或更多孩子以及有榻榻米或地毯地板的家庭中显著较高。这些结果表明，室内内毒素浓度除了与室外内毒素浓度有关外，还与家庭特征有关。
