Leonardi Michela, Librado Pablo, Der Sarkissian Clio, Schubert Mikkel, Alfarhan Ahmed H, Alquraishi Saleh A, Al-Rasheid Khaled A S, Gamba Cristina, Willerslev Eske, Orlando Ludovic
Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade, Copenhagen, Denmark.
Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
Syst Biol. 2017 Jan 1;66(1):e1-e29. doi: 10.1093/sysbio/syw059.
Ever since its emergence in 1984, the field of ancient DNA has struggled to overcome the challenges related to the decay of DNA molecules in the fossil record. With the recent development of high-throughput DNA sequencing technologies and molecular techniques tailored to ultra-damaged templates, it has now come of age, merging together approaches in phylogenomics, population genomics, epigenomics, and metagenomics. Leveraging on complete temporal sample series, ancient DNA provides direct access to the most important dimension in evolution—time, allowing a wealth of fundamental evolutionary processes to be addressed at unprecedented resolution. This review taps into the most recent findings in ancient DNA research to present analyses of ancient genomic and metagenomic data.
自1984年诞生以来，古DNA领域一直在努力克服与化石记录中DNA分子衰变相关的挑战。随着高通量DNA测序技术以及针对超损伤模板的分子技术的最新发展，该领域如今已走向成熟，将系统发育基因组学、群体基因组学、表观基因组学和宏基因组学的方法融合在一起。借助完整的时间样本序列，古DNA提供了直接接触进化中最重要维度——时间的途径，使大量基本进化过程得以以前所未有的分辨率进行研究。本综述利用古DNA研究的最新发现，对古代基因组和宏基因组数据进行分析。
