Mikkelsen H B
Scand J Dent Res. 1978 Sep;86(5):313-24. doi: 10.1111/j.1600-0722.1978.tb00634.x.
The effects of a large dose of vinblastine sulfate (2 mg/kg body weight) on proliferating odontoblast precursors and secretory odontoblasts in the continuously growing rat incisor were studied. The rats were killed 6 h, 24 h, 3 d and 7 d after vinblastine injection. Most cells in the proliferating zone contained arrested mitoses, or had perished after 24 h. After 3 and 7 d, the odontoblasts derived from this zone were reduced in number, and showed altered cell shapes. The odontoblasts had produced irregular dentin. The secretory odontoblasts had displaced nuclei and altered cell shapes after 24 h. Those most affected were opposite early mineralized dentin. In some incisors the cells had perished. In the protracted experiments almost all the odontoblasts were changed and had produced abnormal dentin. In the early mineralized dentin area, accumulations of cells were present after 3 d, and osteodentin-like material after 7 d.
研究了大剂量硫酸长春碱（2毫克/千克体重）对持续生长的大鼠切牙中增殖期成牙本质细胞前体和分泌期成牙本质细胞的影响。在注射长春碱后6小时、24小时、3天和7天处死大鼠。增殖区的大多数细胞含有停滞的有丝分裂，或在24小时后死亡。3天和7天后，源自该区域的成牙本质细胞数量减少，细胞形态改变。成牙本质细胞产生了不规则的牙本质。24小时后，分泌期成牙本质细胞核移位，细胞形态改变。受影响最严重的是与早期矿化牙本质相对的部位。在一些切牙中，细胞已经死亡。在长期实验中，几乎所有的成牙本质细胞都发生了变化，并产生了异常牙本质。在早期矿化牙本质区域，3天后出现细胞聚集，7天后出现类骨样牙本质物质。
