De Oliveira Noguiera T, Stene T, Koppang H S
Scand J Dent Res. 1980 Feb;88(1):15-21. doi: 10.1111/j.1600-0722.1980.tb00714.x.
Colchicine in doses of 0.5, 1.0 and 1.5 mg/kg was administered to 15 rats divided in three experimental groups. Histomorphologic investigation of the maxillary incisors after 2 weeks revealed; 1) alterations in the odontoblasts mainly related to size, shape, polarity and staining properties, and 2) presence of irregular dentin separated from normal dentin by one or two incremental lines. The dentinal irregularities were dose-dependent and consisted of twisting of the dentinal tubules, globular formations and cellular inclusions in addition to niche-like defects.
将秋水仙碱以0.5、1.0和1.5毫克/千克的剂量给予分为三个实验组的15只大鼠。2周后对上颌切牙进行组织形态学研究发现：1）成牙本质细胞出现改变，主要涉及大小、形状、极性和染色特性；2）存在不规则牙本质，与正常牙本质被一到两条生长线分隔开。牙本质不规则性呈剂量依赖性，除了龛样缺陷外，还包括牙本质小管扭曲、球状结构和细胞内含物。
