Stene T, Koppang H S
Scand J Dent Res. 1980 Apr;88(2):104-12. doi: 10.1111/j.1600-0722.1980.tb01201.x.
0.7 mg/kg VCR was administered intravenously to nine rats in three experimental groups. One hour after VCR injection the animals were injected with 3H-proline. The animals were sacrificed 1.5, 5 and 24 h after the VCR administration, and by comparison with nine control animals similarly injected with sodium chloride solution and 3H-proline, it was shown that VCR causes an early, intracellular retention of labeled proline in the odontoblasts, an abnormal intracellular distribution of labeled material and a generally decreased secretion of dentinal matrix from the odontoblasts in the maxillary incisors. The severity of the effects were shown to vary in different parts of the incisors.
向三个实验组的九只大鼠静脉注射0.7毫克/千克的长春新碱。注射长春新碱一小时后，给这些动物注射3H-脯氨酸。在注射长春新碱后1.5小时、5小时和24小时处死动物，并与同样注射氯化钠溶液和3H-脯氨酸的九只对照动物进行比较，结果表明长春新碱导致成牙本质细胞中标记脯氨酸的早期细胞内滞留、标记物质的细胞内分布异常以及上颌切牙中成牙本质细胞牙本质基质分泌普遍减少。结果显示，这些影响的严重程度在切牙的不同部位有所不同。
