Stene T
Scand J Dent Res. 1979 Feb;87(1):39-49. doi: 10.1111/j.1600-0722.1979.tb01938.x.
Vincristine was administered to 60 rats in four groups in doses of 0.1, 0.3, 0.5 and 0.7 mg/kg. Histomorphologic investigation of the dentin and odontoblasts in the maxillary incisors after 1, 2 and 3 weeks revealed a moderate to severe disturbance of dentin production in some parts of the incisors. In some of the affected areas the effect seemed to be reversible in that normal-appearing dentin was found pulpal to the dentinal derangements after 2 and 3 weeks. The distribution and severity of the lesions were similar to those previously observed 3 days after injection of the same doses of vincristine.
将60只大鼠分为四组，分别给予剂量为0.1、0.3、0.5和0.7mg/kg的长春新碱。在1周、2周和3周后对上颌切牙的牙本质和成牙本质细胞进行组织形态学研究，结果显示切牙某些部位的牙本质生成受到中度至重度干扰。在一些受影响的区域，这种影响似乎是可逆的，因为在2周和3周后，在牙本质紊乱的牙髓侧发现了外观正常的牙本质。病变的分布和严重程度与之前注射相同剂量长春新碱3天后观察到的相似。
