美国多种基因型口腔人乳头瘤病毒感染的患病率及危险因素
Prevalence of and Risk Factors for Oral Human Papillomavirus Infection With Multiple Genotypes in the United States.
作者信息
Bui Thanh Cong, Tran Ly Thi-Hai, Thai Thuy Nhu, Shete Sanjay S, Vidrine Damon J, Sturgis Erich M
机构信息
From the *Department of Family and Preventative Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK; †Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX; ‡Department of Epidemiology and Biostatistics, College of Public Health, The University of Georgia, Athens, GA; § Division of Quantitative Sciences, Department of Biostatistics, and ¶ Division of Surgery, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX.
出版信息
Sex Transm Dis. 2017 Mar;44(3):166-172. doi: 10.1097/OLQ.0000000000000563.
BACKGROUND
This study investigated the prevalence of and risk factors for oral human papillomavirus (HPV) infection with multiple genotypes in the United States.
METHODS
Data were from the nationally representative 2009-2012 National Health and Nutrition Examination Survey. This analysis comprised 9257 participants for whom data on oral HPV (37 genotypes) and associated risk factors were available.
RESULTS
The weighted prevalence of multitype (2-6 types) oral HPV infection was 1.5% (2.5% for men, 0.4% for women) in the whole sample and 19.7% (22.0% for men, 12.1% for women) in those who had any type of oral HPV positivity. Most multitype oral HPV cases (83.8%) harbored one or more oncogenic types. In the adjusted multinominal logistic regression model, being male (relative risk ratio [RRR] = 3.69; 95% confidence interval [CI], 1.57-8.65), being a current cigarette smoker (RRR = 2.57; 95% CI, 1.23-5.36), and having a new sex partner in the past year (RRR = 2.10; 95% CI, 1.03-4.28) were associated with an increased risk of multitype oral HPV infection over single-type HPV infection.
CONCLUSIONS
Men, smokers, and those who had new sexual partners were at a significantly higher risk for multitype oral HPV infection.
背景
本研究调查了美国多种基因型口腔人乳头瘤病毒（HPV）感染的患病率及危险因素。
方法
数据来自具有全国代表性的2009 - 2012年国家健康与营养检查调查。该分析纳入了9257名参与者，他们有口腔HPV（37种基因型）及相关危险因素的数据。
结果
在整个样本中，多型（2 - 6种类型）口腔HPV感染的加权患病率为1.5%（男性为2.5%，女性为0.4%），在任何类型口腔HPV呈阳性的人群中为19.7%（男性为22.0%，女性为12.1%）。大多数多型口腔HPV病例（83.8%）携带一种或多种致癌型别。在调整后的多项逻辑回归模型中，男性（相对风险比[RRR]=3.69；95%置信区间[CI]，1.57 - 8.65）、当前吸烟者（RRR = 2.57；95% CI，1.23 - 5.36）以及在过去一年中有新性伴侣（RRR = 2.10；95% CI，1.03 - 4.28）与单型HPV感染相比，多型口腔HPV感染风险增加相关。
结论
男性、吸烟者以及有新性伴侣者感染多型口腔HPV的风险显著更高。
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