大蒜素对双态真菌巴西副球孢子菌生长的抑制作用
Inhibition of growth of the dimorphic fungus Paracoccidioides brasiliensis by ajoene.
作者信息
San-Blas G, San-Blas F, Gil F, Mariño L, Apitz-Castro R
机构信息
Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Carcas, Venezuela.
出版信息
Antimicrob Agents Chemother. 1989 Sep;33(9):1641-4. doi: 10.1128/AAC.33.9.1641.
Abstract
Ajoene, a garlic-derived compound that prevents platelet activation, inhibited the growth of Paracoccidioides brasiliensis, a fungal pathogen for humans, by affecting the integrity of the fungal cytoplasmic membrane. This action may be the basis for the study of ajoene as a possible specific antifungal drug.
摘要
大蒜衍生化合物阿霍烯可防止血小板活化，它通过影响真菌细胞质膜的完整性，抑制了人类真菌病原体巴西副球孢子菌的生长。这一作用可能是将阿霍烯作为一种可能的特异性抗真菌药物进行研究的基础。
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