Sharen Gaowa, Peng Yaojun, Cheng Haidong, Liu Yang, Shi Yonghong, Zhao Jian
Cancer Center Key Laboratory, Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, P. R. China.
Molecular Pathology Laboratory, College of Basic Medicine, Inner Mongolia Medical University, Inner Mongolia 010059, P. R. China.
Oncotarget. 2017 Mar 21;8(12):19760-19767. doi: 10.18632/oncotarget.15035.
Previous studies have suggested a correlation between glucose transporter-1 (GLUT-1) expression and survival outcomes in pancreatic cancer, although the results were inconsistent. We subsequently carried out a meta-analysis, with the aim of comprehensively reevaluating the associations between GLUT-1 expression and overall survival (OS) and other clinical features of pancreatic cancer.
Eight studies, with a total of 538 cases, were included in the final meta-analysis. The HR and 95% CI for OS were 1.79 and 1.19-2.7, respectively (p=0.005). GLUT-1 overexpression was associated with tumor size (>2 cm vs. ≤2 cm; OR=2.16, 95% CI=1.2-3.9, p=0.01) and lymph node metastasis (yes vs. no; OR=3.29, 95% CI=1.38-7.84, p=0.007). However, there was no significant association between GLUT-1 expression and histological grade, age, sex, TNM stage, or vascular invasion status. There was no evidence of significant publication bias in this meta-analysis.
Relevant databases were searched using predefined searching items until September 2016. The pooled hazard ratios (HR) with 95% confidence interval (CI) for OS and the pooled odds ratio (OR) with 95% CI for clinical factors were calculated.
High GLUT-1 expression predicted shorter OS in patients with pancreatic cancer. Moreover, GLUT-1 expression was associated with a tumor size of >2 cm and presence of lymph node metastasis.
既往研究提示葡萄糖转运蛋白1（GLUT-1）表达与胰腺癌生存结局之间存在相关性，尽管结果并不一致。随后我们进行了一项荟萃分析，旨在全面重新评估GLUT-1表达与胰腺癌总生存期（OS）及其他临床特征之间的关联。
最终的荟萃分析纳入了8项研究，共538例病例。OS的HR及95%CI分别为1.79和1.19 - 2.7（p = 0.005）。GLUT-1过表达与肿瘤大小（>2 cm对≤2 cm；OR = 2.16，95%CI = 1.2 - 3.9，p = 0.01）及淋巴结转移（有对无；OR = 3.29，95%CI = 1.38 - 7.84，p = 0.007）相关。然而，GLUT-1表达与组织学分级、年龄、性别、TNM分期或血管侵犯状态之间无显著关联。该荟萃分析无显著发表偏倚的证据。
使用预定义的检索词检索相关数据库至2016年9月。计算OS的合并风险比（HR）及95%置信区间（CI），以及临床因素的合并比值比（OR）及95%CI。
GLUT-1高表达预示胰腺癌患者OS较短。此外，GLUT-1表达与肿瘤大小>2 cm及存在淋巴结转移相关。
