Duffy Joseph R, Strand Edythe A, Josephs Keith A
Dept. of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, U.S.A.
Aphasiology. 2014 Aug;28(8-9):1004-1017. doi: 10.1080/02687038.2013.869307.
Primary progressive aphasia (PPA) and conditions that overlap with it can be accompanied by motor speech disorders. Recognition and understanding of motor speech disorders can contribute to a fuller clinical understanding of PPA and its management as well as its localization and underlying pathology.
To review the types of motor speech disorders that may occur with PPA, its primary variants, and its overlap syndromes (progressive supranuclear palsy syndrome, corticobasal syndrome, motor neuron disease), as well as with primary progressive apraxia of speech.
The review should assist clinicians' and researchers' understanding of the relationship between motor speech disorders and PPA and its major variants. It also highlights the importance of recognizing neurodegenerative apraxia of speech as a condition that can occur with little or no evidence of aphasia.
Motor speech disorders can occur with PPA. Their recognition can contribute to clinical diagnosis and management of PPA and to understanding and predicting the localization and pathology associated with PPA variants and conditions that can overlap with them.
原发性进行性失语（PPA）及其重叠病症可能伴有运动性言语障碍。认识和理解运动性言语障碍有助于更全面地临床了解PPA及其管理，以及其定位和潜在病理。
回顾可能与PPA、其主要变异型及其重叠综合征（进行性核上性麻痹综合征、皮质基底节综合征、运动神经元病）以及原发性进行性言语失用症同时出现的运动性言语障碍类型。
该综述应有助于临床医生和研究人员理解运动性言语障碍与PPA及其主要变异型之间的关系。它还强调了认识神经退行性言语失用症的重要性，这种病症可能在几乎没有或没有失语证据的情况下出现。
PPA可能伴有运动性言语障碍。对它们的认识有助于PPA的临床诊断和管理，以及理解和预测与PPA变异型及其可能重叠的病症相关的定位和病理。
