Cesari Matteo, Landi Francesco, Calvani Riccardo, Cherubini Antonio, Di Bari Mauro, Kortebein Patrick, Del Signore Susanna, Le Lain Regis, Vellas Bruno, Pahor Marco, Roubenoff Ronenn, Bernabei Roberto, Marzetti Emanuele
Gérontopôle, Centre Hospitalier Universitaire de Toulouse III, Paul Sabatier, 37 Allées Jules Guesde, 31000, Toulouse, France.
Université de Toulouse III Paul Sabatier, Toulouse, France.
Aging Clin Exp Res. 2017 Feb;29(1):81-88. doi: 10.1007/s40520-016-0716-1. Epub 2017 Feb 10.
In the present article, the rationale that guided the operationalization of the theoretical concept of physical frailty and sarcopenia (PF&S), the condition of interest for the "Sarcopenia and Physical Frailty in Older People: Multicomponent Treatment Strategies" (SPRINTT) trial, is presented. In particular, the decisions lead to the choice of the adopted instruments, and the reasons for setting the relevant thresholds are explained. In SPRINTT, the concept of physical frailty is translated with a Short Physical Performance Battery score of ≥3 and ≤9. Concurrently, sarcopenia is defined according to the recent definitions of low muscle mass proposed by the Foundation for the National Institutes of Health-Sarcopenia Project. Given the preventive purpose of SPRINTT, older persons with mobility disability (operationalized as incapacity to complete a 400-m walk test within 15 min; primary outcome of the trial) at the baseline are not included within the diagnostic spectrum of PF&S.
在本文中，我们阐述了指导“老年人肌肉减少症与身体虚弱：多组分治疗策略”（SPRINTT）试验所关注的身体虚弱和肌肉减少症（PF&S）这一理论概念实施的基本原理。具体而言，解释了做出导致采用所选工具的决策以及设定相关阈值的原因。在SPRINTT中，身体虚弱的概念通过短身体性能测试电池评分≥3且≤9来体现。同时，肌肉减少症是根据美国国立卫生研究院肌肉减少症项目基金会提出的近期低肌肉量定义来界定的。鉴于SPRINTT的预防目的，基线时存在行动障碍（定义为无法在15分钟内完成400米步行测试；该试验的主要结局）的老年人不纳入PF&S的诊断范围。
