Richter Yvonne, Lind Pedro G, Seemann Gunnar, Maass Philipp
Fachbereich Physik, Universität Osnabrück, Barbarastraße 7, 49076 Osnabrück, Germany.
Fachbereich Physik, Universität Osnabrück, Barbarastraße 7, 49076 Osnabrück, Germany.
J Theor Biol. 2017 Apr 21;419:100-107. doi: 10.1016/j.jtbi.2017.02.008. Epub 2017 Feb 10.
For modeling the propagation of action potentials in the human atria, various models have been developed in the past, which take into account in detail the influence of the numerous ionic currents flowing through the cell membrane. Aiming at a simplified description, the Bueno-Orovio-Cherry-Fenton (BOCF) model for electric wave propagation in the ventricle has been adapted recently to atrial physiology. Here, we study this adapted BOCF (aBOCF) model with respect to its capability to accurately generate spatio-temporal excitation patterns found in anatomical and spiral wave reentry. To this end, we compare results of the aBOCF model with the more detailed one proposed by Courtemanche, Ramirez and Nattel (CRN model). We find that characteristic features of the reentrant excitation patterns seen in the CRN model are well captured by the aBOCF model. This opens the possibility to study origins of atrial fibrillation based on a simplified but still reliable description.
为了模拟动作电位在人体心房中的传播，过去已经开发了各种模型，这些模型详细考虑了流经细胞膜的众多离子电流的影响。为了进行简化描述，最近已将用于心室电波传播的布埃诺 - 奥罗维奥 - 切里 - 芬顿（BOCF）模型应用于心房生理学。在这里，我们研究这个经过修改的BOCF（aBOCF）模型，考察其准确生成在解剖学和螺旋波折返中发现的时空兴奋模式的能力。为此，我们将aBOCF模型的结果与库尔特曼什、拉米雷斯和纳特尔提出的更详细的模型（CRN模型）进行比较。我们发现，aBOCF模型很好地捕捉到了CRN模型中所见折返兴奋模式的特征。这为基于简化但仍然可靠的描述来研究心房颤动的起源开辟了可能性。
