人和大鼠的尿多巴胺：无机盐对多巴胺排泄的影响。

Urinary dopamine in man and rat: effects of inorganic salts on dopamine excretion.

Ball S G, Oats N S, Lee M R

Clin Sci Mol Med. 1978 Aug;55(2):167-73. doi: 10.1042/cs0550167.

Abstract

Plasma and urine free dopamine (3,4-dihydroxyphenethylamine) were measured in six normal male volunteer subjects and the urinary clearance of dopamine was calculated for each subject. 2. The excretion rates for free dopamine in man were greater than could be explained by simple renal clearance. It was concluded that free dopamine must, therefore, be formed in the kidney. 3. Changes in urinary dopamine excretion were studied in four groups of rats initially maintained on low sodium diet and then given equimolar dietary supplements of NaCl, NaHCO3, KCl or NH4Cl, to study the specificity of the previously observed increase in dopamine excretion after increased dietary NaCl. 4. The mean dopamine excretion increased significantly in rats given NaCl, KCl and NH4Cl, whereas dopamine excretion decreased in those given NaHCO3. 5. The failure of dopamine excretion to rise in response to loading with NaHCO3 was unexpected, and argues against a simple effect of volume expansion by the sodium ion. The increase in dopamine excretion with KCl and NH4Cl showed that this response was not specific to the sodium ion.

摘要

对6名正常男性志愿者受试者测定了血浆和尿中的游离多巴胺（3,4 - 二羟基苯乙胺），并计算了每位受试者多巴胺的尿清除率。2. 人体中游离多巴胺的排泄率高于单纯经肾清除所能解释的水平。因此得出结论，游离多巴胺必定是在肾脏中生成的。3. 对四组大鼠的尿多巴胺排泄变化进行了研究，这些大鼠最初维持低钠饮食，然后给予等摩尔的NaCl、NaHCO₃、KCl或NH₄Cl饮食补充剂，以研究先前观察到的饮食中NaCl增加后多巴胺排泄增加的特异性。4. 给予NaCl、KCl和NH₄Cl的大鼠多巴胺平均排泄量显著增加，而给予NaHCO₃的大鼠多巴胺排泄量减少。5. 多巴胺排泄量对NaHCO₃负荷无反应出乎意料，这与钠离子引起的单纯容量扩张效应相悖。KCl和NH₄Cl使多巴胺排泄增加表明这种反应并非钠离子所特有。