Shang Yu, Li Ting, Yu Guoqiang
Key Laboratory of Instrumentation Science & Dynamic Measurement, North University of China, No.3 Xueyuan Road Taiyuan, Shanxi 030051, People's Republic of China.
Physiol Meas. 2017 Apr;38(4):R1-R26. doi: 10.1088/1361-6579/aa60b7. Epub 2017 Feb 15.
Blood flow is one such available observable promoting a wealth of physiological insight both individually and in combination with other metrics.
Near-infrared diffuse correlation spectroscopy (DCS) and, to a lesser extent, diffuse correlation tomography (DCT), have increasingly received interest over the past decade as noninvasive methods for tissue blood flow measurements and imaging. DCS/DCT offers several attractive features for tissue blood flow measurements/imaging such as noninvasiveness, portability, high temporal resolution, and relatively large penetration depth (up to several centimeters).
This review first introduces the basic principle and instrumentation of DCS/DCT, followed by presenting clinical application examples of DCS/DCT for the diagnosis and therapeutic monitoring of diseases in a variety of organs/tissues including brain, skeletal muscle, and tumor.
Clinical study results demonstrate technical versatility of DCS/DCT in providing important information for disease diagnosis and intervention monitoring.
血流是一种可观察到的指标,它既能单独为生理洞察提供丰富信息,也能与其他指标相结合发挥作用。
近红外扩散相关光谱法(DCS),以及在较小程度上的扩散相关断层扫描法(DCT),在过去十年中越来越受到关注,成为用于组织血流测量和成像的非侵入性方法。DCS/DCT在组织血流测量/成像方面具有几个吸引人的特性,如非侵入性、便携性、高时间分辨率以及相对较大的穿透深度(可达几厘米)。
本综述首先介绍DCS/DCT的基本原理和仪器设备,接着展示DCS/DCT在包括脑、骨骼肌和肿瘤等多种器官/组织疾病诊断和治疗监测方面的临床应用实例。
临床研究结果证明了DCS/DCT在为疾病诊断和干预监测提供重要信息方面的技术多功能性。