Department of Sport and Health Sciences, Institute of Preventive Pediatrics, Technische Universität München, München, Germany.
Hypertens Res. 2017 Jul;40(7):675-678. doi: 10.1038/hr.2017.19. Epub 2017 Feb 16.
The relationship between cardiorespiratory fitness and arterial compliance in children and adolescents remains controversial. The aim of this study was to assess this association with a quantitative approach. A total of 646 healthy children and adolescents (316 females, age 13.9±2.1 years) were cross-sectionally investigated in seven school settings in and around Munich for their cardiorespiratory fitness and demographic, anthropometric and hemodynamic parameters. Surrogates of arterial stiffness, such as pulse wave velocity (PWV), Augmentation Index normalized to a heart rate of 75 (AI@75), and peripheral and central systolic blood pressures were measured in a supine position using the oscillometric Mobil-O-Graph. Cardiopulmonary fitness was measured by 6-min indoor run tests. After correction for age, sex, body weight, body height, heart rate and mean arterial pressure, controversial findings were produced. PWV increased with higher cardiorespiratory fitness (Beta=0.173; P<0.001), which represented an unfavorable relationship, whereas AI@75 declined with higher cardiorespiratory fitness (Beta=-0.106; P=0.025). Therefore, in contrast to PWV, higher cardiorespiratory fitness seems beneficial for AI@75. The third surrogate of arterial stiffness, central systolic blood pressure, showed no association with cardiorespiratory fitness (Beta=0.066; P=0.052). These controversial outcomes remain almost unchanged when the boys and girls were analyzed separately. Different surrogates of arterial stiffness have different relationships with cardiorespiratory fitness in children and adolescents after correcting for multiple confounders. More research is needed in this field to understand the functioning of the juvenile vessels, and measurements and methodological approaches should be reconsidered.
儿童和青少年的心肺适能与动脉顺应性之间的关系仍然存在争议。本研究旨在通过定量方法评估这种相关性。在慕尼黑及其周边的七个学校环境中，共对 646 名健康的儿童和青少年（316 名女性，年龄 13.9±2.1 岁）进行了横断面研究，以评估他们的心肺适能以及人口统计学、人体测量学和血液动力学参数。使用示波法 Mobil-O-Graph 在仰卧位测量动脉僵硬度的替代指标，如脉搏波速度（PWV）、心率为 75 时的归一化增强指数（AI@75）以及外周和中心收缩压。心肺适能通过 6 分钟室内跑步测试进行测量。在校正年龄、性别、体重、身高、心率和平均动脉压后，得出了有争议的发现。PWV 随着心肺适能的增加而增加（Beta=0.173；P<0.001），这代表了一种不利的关系，而 AI@75 随着心肺适能的增加而降低（Beta=-0.106；P=0.025）。因此，与 PWV 相反，更高的心肺适能似乎对 AI@75 有益。动脉僵硬度的第三个替代指标，中心收缩压，与心肺适能没有关联（Beta=0.066；P=0.052）。当分别分析男孩和女孩时，这些有争议的结果几乎保持不变。在纠正了多个混杂因素后，不同的动脉僵硬度替代指标与儿童和青少年的心肺适能之间存在不同的关系。在这一领域需要进行更多的研究，以了解青少年血管的功能，并且应该重新考虑测量和方法学方法。
