Müller Jan, Taebling Marius, Oberhoffer Renate
Institute of Preventive Pediatrics, Technische Universität München, Munich, Germany.
Front Physiol. 2019 Aug 21;10:1094. doi: 10.3389/fphys.2019.01094. eCollection 2019.
Remote ischemic preconditioning (RIPC) are short episodes of ischemia and reperfusion applied to remote tissue to trigger responses in a specific organ or cardiovascular bed. This study investigates whether RIPC has a short-term effect on blood pressure (BP), heart rate, and arterial stiffness.
From March 2018 to August 2018, we included 40 healthy volunteers (23 female, age 25.6 ± 2.8 years) into this single-blinded randomized-controlled crossover trial. After measuring BP, heart rate, and arterial stiffness in supine position participants were randomized into intervention or SHAM group. The intervention group then underwent a RIPC protocol (3 cycles of 5 min of 200 mmHg ischemia followed by 5 min reperfusion) at the thigh. The SHAM group followed the same protocol just on the upper arm with 40 mmHg pressure inflation. Directly after this 30-min procedure a reassessment of hemodynamic measures was conducted.
There were no significant changes in all five outcome parameters when comparing the effect of RIPC to SHAM. In peripheral systolic BP the mean difference between groups was Δ1.14 ± 6.5 mmHg ( = 0.672), and for diastolic BP Δ-0.69 ± 4.5 mmHg ( = 0.507). Heart rate shoed a Δ-0.8 ± 4.7 beats/min ( = 0.397). Regarding arterial stiffness measures, there was also no significant improvements thru RIPC. The mean difference between RIPC and SHAM for central systolic BP was Δ0.40 ± 7.2 mmHg ( = 0.951) and for PWV Δ0.01 ± 0.26 m/s ( = 0.563).
This study could not find any short-term effects of RIPC on arterial stiffness, BP, and heart rate in a RCT in young healthy adults.
远程缺血预处理（RIPC）是对远程组织进行的短暂缺血和再灌注，以触发特定器官或心血管床的反应。本研究调查RIPC对血压（BP）、心率和动脉僵硬度是否有短期影响。
2018年3月至2018年8月，我们将40名健康志愿者（23名女性，年龄25.6±2.8岁）纳入这项单盲随机对照交叉试验。在测量仰卧位的血压、心率和动脉僵硬度后，参与者被随机分为干预组或假手术组。干预组随后在大腿处进行RIPC方案（3个周期，每个周期200 mmHg缺血5分钟，然后再灌注5分钟）。假手术组仅在上臂以40 mmHg压力充气，遵循相同方案。在这个30分钟的程序结束后，立即对血流动力学指标进行重新评估。
比较RIPC与假手术的效果时，所有五个结果参数均无显著变化。外周收缩压组间平均差异为Δ1.14±6.5 mmHg（P = 0.672），舒张压为Δ-0.69±4.5 mmHg（P = 0.507）。心率显示Δ-0.8±4.7次/分钟（P = 0.397）。关于动脉僵硬度指标，RIPC也没有显著改善。RIPC与假手术组中心收缩压的平均差异为Δ0.40±7.2 mmHg（P = 0.951），脉搏波速度为Δ0.01±0.26 m/s（P = 0.563）。
在一项针对年轻健康成年人的随机对照试验中，本研究未发现RIPC对动脉僵硬度、血压和心率有任何短期影响。
