氨苄西林和庆大霉素耐药决定子的结构与转移
Structure and mobilization of an ampicillin and gentamicin resistance determinant.
作者信息
Martin C, Gomez-Lus R, Ortiz J M, Garcia-Lobo J M
出版信息
Antimicrob Agents Chemother. 1987 Aug;31(8):1266-70. doi: 10.1128/AAC.31.8.1266.
A DNA segment originally found in an epidemic plasmid of Escherichia coli encoding an aminoglycoside-(3)-N-acetyltransferase gene (aacC5) and a TEM-type beta-lactamase gene was characterized. The two genes were adjacent and constituted a single transcriptional unit. In addition, these genes were simultaneously mobilized through the action of an insertion sequence related to IS26, IS140, and IS15-delta. This DNA segment is a composite transposon which has been called Tn2922.
一个最初在大肠杆菌的流行质粒中发现的DNA片段被鉴定，该片段编码一个氨基糖苷 -（3）-N - 乙酰转移酶基因（aacC5）和一个TEM型β - 内酰胺酶基因。这两个基因相邻并构成一个单一的转录单元。此外，这些基因通过与IS26、IS140和IS15 - δ相关的插入序列的作用同时被转移。这个DNA片段是一个复合转座子，被称为Tn2922。
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