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本文引用的文献

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Overlooked Risk for Chronic Kidney Disease after Leptospiral Infection: A Population-Based Survey and Epidemiological Cohort Evidence.钩端螺旋体感染后慢性肾脏病被忽视的风险：一项基于人群的调查和流行病学队列证据
PLoS Negl Trop Dis. 2015 Oct 9;9(10):e0004105. doi: 10.1371/journal.pntd.0004105. eCollection 2015.
2
Seroepidemiology of leptospirosis in dogs from rural and slum communities of Los Rios Region, Chile.智利洛斯里奥斯地区农村和贫民窟社区狗的钩端螺旋体病血清流行病学。
BMC Vet Res. 2015 Feb 12;11:31. doi: 10.1186/s12917-015-0341-9.
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Changes in kidney function among Nicaraguan sugarcane workers.尼加拉瓜甘蔗工人的肾功能变化。
Int J Occup Environ Health. 2015 Jul-Sep;21(3):241-50. doi: 10.1179/2049396714Y.0000000102. Epub 2015 Jan 28.
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The epidemic of chronic kidney disease in Central America.中美洲的慢性肾病流行情况。
Lancet Glob Health. 2014 Aug;2(8):e440-1. doi: 10.1016/S2214-109X(14)70217-7. Epub 2014 Jun 24.
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Long term outcome of acute kidney injury due to leptospirosis? A longitudinal study in Sri Lanka.钩端螺旋体病所致急性肾损伤的长期预后？斯里兰卡的一项纵向研究。
BMC Res Notes. 2014 Jun 25;7:398. doi: 10.1186/1756-0500-7-398.
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Epidemiology of chronic kidney disease in adults of Salvadoran agricultural communities.萨尔瓦多农业社区成年人群慢性肾脏病的流行病学
MEDICC Rev. 2014 Apr;16(2):23-30. doi: 10.37757/MR2014.V16.N2.5.
7
Risk factors for reduced glomerular filtration rate in a Nicaraguan community affected by Mesoamerican nephropathy.受中美洲肾病影响的尼加拉瓜社区中肾小球滤过率降低的危险因素。
MEDICC Rev. 2014 Apr;16(2):16-22. doi: 10.37757/MR2014.V16.N2.4.
8
CKD of unknown origin in Central America: the case for a Mesoamerican nephropathy.中美洲不明原因的慢性肾脏病：中美洲肾病的案例。
Am J Kidney Dis. 2014 Mar;63(3):506-20. doi: 10.1053/j.ajkd.2013.10.062. Epub 2014 Jan 10.
9
A basic science view of acute kidney injury biomarkers.急性肾损伤生物标志物的基础科学观。
Nephrol Dial Transplant. 2014 Jul;29(7):1301-11. doi: 10.1093/ndt/gft510. Epub 2014 Jan 2.
10
Resolving the enigma of the mesoamerican nephropathy: a research workshop summary.解析中美洲肾病之谜：研究研讨会总结。
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钩端螺旋体血清阳性作为中美洲肾病的一个危险因素。

Leptospira seropositivity as a risk factor for Mesoamerican Nephropathy.

作者信息

Riefkohl Alejandro, Ramírez-Rubio Oriana, Laws Rebecca L, McClean Michael D, Weiner Daniel E, Kaufman James S, Galloway Renee L, Shadomy Sean V, Guerra Marta, Amador Juan José, Sánchez José Marcel, López-Pilarte Damaris, Parikh Chirag R, Leibler Jessica H, Brooks Daniel R

机构信息

a Department of Epidemiology , Boston University School of Public Health , Boston , MA , USA.

b Preventive Medicine and Public Health Department , Universidad Autónoma de Madrid , Madrid , Spain.

出版信息

Int J Occup Environ Health. 2017 Jan;23(1):1-10. doi: 10.1080/10773525.2016.1275462. Epub 2017 Feb 17.

DOI:10.1080/10773525.2016.1275462
PMID:28209095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6060841/
Abstract

BACKGROUND

Leptospirosis is postulated as a possible cause of Mesoamerican Nephropathy (MeN) in Central American workers.

OBJECTIVES

Investigate job-specific Leptospira seroprevalence and its association with kidney disease biomarkers.

METHODS

In 282 sugarcane workers, 47 sugarcane applicants and 160 workers in other industries, we measured anti-leptospiral antibodies, serum creatinine, and urinary injury biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), and N-acetyl-D-glucosaminidase (NAG).

RESULTS

Leptospira seroprevalence differed among job categories and was highest among sugarcane cutters (59%). Seropositive sugarcane workers had higher NGAL concentrations (relative mean: 1.28; 95% CI: 0.94-1.75) compared to those who were seronegative, with similar findings among field and non-field workers.

CONCLUSIONS

Leptospira seroprevalence varied by job category. There was some indication that seropositivity was associated with elevated biomarker levels, but results were inconsistent. Additional studies may help establish whether Leptospira infection plays any role in MeN among Central American workers.

摘要

背景

钩端螺旋体病被认为是中美洲工人患中美洲肾病（MeN）的一个可能原因。

目的

调查特定工作的钩端螺旋体血清阳性率及其与肾脏疾病生物标志物的关联。

方法

在282名甘蔗工人、47名甘蔗求职者和160名其他行业工人中，我们检测了抗钩端螺旋体抗体、血清肌酐和尿损伤生物标志物，包括中性粒细胞明胶酶相关脂质运载蛋白（NGAL）、白细胞介素-18（IL-18）和N-乙酰-D-氨基葡萄糖苷酶（NAG）。

结果

钩端螺旋体血清阳性率在不同工作类别中存在差异，甘蔗砍伐工中最高（59%）。与血清阴性的甘蔗工人相比，血清阳性的甘蔗工人NGAL浓度更高（相对均值：1.28；95%可信区间：0.94 - 1.75），在田间和非田间工人中也有类似发现。

结论

钩端螺旋体血清阳性率因工作类别而异。有迹象表明血清阳性与生物标志物水平升高有关，但结果并不一致。更多研究可能有助于确定钩端螺旋体感染在中美洲工人的MeN中是否起作用。