From the Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, OH.
Circ Res. 2017 Feb 17;120(4):627-629. doi: 10.1161/CIRCRESAHA.116.310058.
The inability of the adult heart to repair or regenerate is manifested in prevalent morbidity and mortality related to myocardial infarction and heart failure. Cardiomyocyte proliferation, especially after myocardial infarction or in the context of heart failure, has been an area of intense research by many investigators for decades. As a researcher working in this area for the past 25 years, this has been an exciting time, requiring an open mind in leaving old accepted ideas behind and moving forward towards exploiting this new knowledge of cardiomyocyte plasticity.
成年心脏无法修复或再生,这表现在与心肌梗死和心力衰竭相关的高发病率和高死亡率上。几十年来,心肌细胞增殖一直是许多研究人员的研究热点,尤其是在心肌梗死后或心力衰竭的情况下。作为该领域过去 25 年的研究人员,这是一个令人兴奋的时期,需要摒弃旧有的既定观念,保持开放的心态,朝着利用心肌细胞可塑性的新知识前进。