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哺乳动物心脏再生：奔向终点线的竞赛。

Mammalian Heart Regeneration: The Race to the Finish Line.

机构信息

From the Division of Experimental Surgery, Department of Cardiovascular Surgery, German Heart Center Munich, Germany (S.A.D., M.-A.D., E.D., R.L., M.K.); Stanford Cardiovascular Institute (V.S., G.L., E.D., S.M.W.), Institute for Stem Cell and Regenerative Medicine (S.M.W.), and Division of Cardiovascular Medicine, Department of Medicine (S.M.W.), Stanford University School of Medicine, CA; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Germany (M.-A.D., M.K.).

出版信息

Circ Res. 2017 Feb 17;120(4):630-632. doi: 10.1161/CIRCRESAHA.116.310051.

DOI:10.1161/CIRCRESAHA.116.310051
PMID:28209796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5321648/
Abstract

A long-standing goal of cardiovascular scientists is to repair damaged hearts following myocardial infarction by overcoming the limited regenerative capacity of the adult mammalian heart. A number of new strategies are being actively investigated for generating functional cardiomyocytes or progenitor cells. The race is on for the first demonstration of durable therapeutic heart repair in human.

摘要

心血管科学家的长期目标是通过克服成年哺乳动物心脏的有限再生能力来修复心肌梗死后受损的心脏。目前正在积极研究许多新策略来生成功能性心肌细胞或祖细胞。目前正在竞相在人体中首次证明持久的治疗性心脏修复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df5e/5321648/b00c73e3282c/nihms838649f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df5e/5321648/b00c73e3282c/nihms838649f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df5e/5321648/b00c73e3282c/nihms838649f1.jpg

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Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors.通过特定因子将成纤维细胞重编程为增殖诱导性心脏祖细胞
Cell Stem Cell. 2016 Mar 3;18(3):354-67. doi: 10.1016/j.stem.2015.12.001. Epub 2016 Feb 11.
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Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction.严重心肌梗死人类新生儿心脏的功能恢复。
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Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report.
用于心脏修复的细胞重编程、转分化和去分化方法。
Int J Mol Sci. 2025 Mar 27;26(7):3063. doi: 10.3390/ijms26073063.
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Harnessing native blueprints for designing bioinks to bioprint functional cardiac tissue.利用天然蓝图设计生物墨水以生物打印功能性心脏组织。
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Therapeutic potential of exosomes derived from human endometrial mesenchymal stem cells for heart tissue regeneration after myocardial infarction.人子宫内膜间充质干细胞来源的外泌体对心肌梗死后心脏组织再生的治疗潜力。
Regen Ther. 2025 Feb 1;28:451-461. doi: 10.1016/j.reth.2025.01.007. eCollection 2025 Mar.
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FSTL-1 loaded 3D bioprinted vascular patch regenerates the ischemic heart tissue.负载FSTL-1的3D生物打印血管补片可使缺血性心脏组织再生。
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