Wei Xin, Hu Hankun, Zheng Baogeng, Arslan Zikri, Huang Hung-Chung, Mao Weidong, Liu Yi-Ming
Wuhan University Zhongnan Hospital, Wuhan 430071, China.
Wuhan University Zhongnan Hospital, Wuhan 430071, China; Wuhan Yaogu Biotech, Ltd. Wuhan 430075, China.
Anal Methods. 2017 Jan 28;9(4):724-728. doi: 10.1039/C6AY02524B. Epub 2017 Jan 9.
() is a natural product that has diverse nutritional and medicinal values. Since the availability of natural becomes limited its authentication and quality control is of high significance. Herein we report on profiling of metals in by using inductively coupled plasma mass spectrometry (ICP-MS). The analysis reveals that contains a wide array of essential elements, including P, Mg, Zn, Cu, Fe, etc. Toxic metals detected are Cd, Pb, and As. In all five samples analyzed Pb contents are below 2.0 ppm. Arsenic level in caterpillar is significantly higher than that in its mycelium and varies from 3.0 to 32 ppm likely due to soil contamination. It's for the first time demonstrated in this work that clustering analysis on the proposed metal profiles consisting of 24 elements is very useful to identify "abnormal" samples, thus adding another dimension to the effective means for authentication and quality assessment of this highly demanded previous natural product.
（）是一种具有多种营养和药用价值的天然产物。由于天然（产物）的可得性变得有限，其鉴定和质量控制具有重要意义。在此，我们报告了使用电感耦合等离子体质谱法（ICP-MS）对（该天然产物）中的金属进行分析。分析表明，（该天然产物）含有多种必需元素，包括磷、镁、锌、铜、铁等。检测到的有毒金属有镉、铅和砷。在所分析的所有五个样品中，铅含量均低于2.0 ppm。（该天然产物）中毛虫体内的砷含量明显高于其菌丝体中的砷含量，且在3.0至32 ppm之间变化，这可能是由于土壤污染所致。这项工作首次表明，对由24种元素组成的金属谱进行聚类分析对于识别“异常”（该天然产物）样品非常有用，从而为这种备受需求的珍贵天然产物的鉴定和质量评估的有效手段增添了另一个维度。
