Ortolani Alessandro, Bianchi Michele, Mosca Massimiliano, Caravelli Silvio, Fuiano Mario, Marcacci Maurilio, Russo Alessandro
Laboratory of Nano Biotechnology (NaBi), Istituto Ortopedico Rizzoli, Bologna, Italy.
I Orthopaedic and Traumatological Clinic, Istituto Ortopedico Rizzoli, Bologna, Italy.
Joints. 2017 Feb 7;4(4):228-235. doi: 10.11138/jts/2016.4.4.228. eCollection 2016 Oct-Dec.
Magnetic scaffolds are becoming increasingly attractive in tissue engineering, due to their ability to enhance bone tissue formation by attracting soluble factors, such as growth factors, hormones and polypeptides, directly to the implantation site, as well as their potential to improve the fixation and stability of the implant. Moreover, there is increasing evidence that the synergistic effects of magnetic scaffolds and magnetic fields can promote bone repair and regeneration. In this manuscript we review the recent innovations in bone tissue engineering that exploit magnetic biomaterials combined with static magnetic fields to enhance bone cell adhesion and proliferation, and thus bone tissue growth.
磁性支架在组织工程中越来越具有吸引力，这是因为它们能够通过将可溶性因子，如生长因子、激素和多肽，直接吸引到植入部位来促进骨组织形成，以及它们具有改善植入物固定和稳定性的潜力。此外，越来越多的证据表明，磁性支架和磁场的协同作用可以促进骨修复和再生。在本手稿中，我们综述了骨组织工程中利用磁性生物材料与静磁场相结合来增强骨细胞黏附与增殖，从而促进骨组织生长的最新创新成果。
