亲脂性胺对甲型肝炎病毒在Frp/3细胞中生长的影响。
The effect of lipophilic amines on the growth of hepatitis A virus in Frp/3 cells.
作者信息
Superti F, Seganti L, Orsi N, Divizia M, Gabrieli R, Panà A
机构信息
Istituto di Microbiologia, Università di Roma La Sapienza, Facoltà di Medicina e Chirurgia, Italy.
出版信息
Arch Virol. 1987;96(3-4):289-96. doi: 10.1007/BF01320970.
The effect of lipophilic amines on hepatitis A virus infection in a monkey cell line (Frp/3 cells) was studied. Ammonium chloride, amantadine, methylamine and dansylcadaverine inhibited viral antigen synthesis when added to the cells at least one hour after the attachment step. Results obtained suggest that the HAV entry pathway in Frp/3 cells follows an endocytic route and that viral uncoating takes probably place in endosomes and/or lysosomes.
研究了亲脂性胺对猴细胞系（Frp/3细胞）中甲肝病毒感染的影响。氯化铵、金刚烷胺、甲胺和丹磺酰尸胺在病毒附着步骤后至少1小时添加到细胞中时，可抑制病毒抗原合成。所得结果表明，Frp/3细胞中甲肝病毒的进入途径遵循内吞途径，病毒脱壳可能发生在内体和/或溶酶体中。
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