氧稳态的系统生物学
Systems biology of oxygen homeostasis.
作者信息
Samanta Debangshu, Prabhakar Nanduri R, Semenza Gregg L
机构信息
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
Wiley Interdiscip Rev Syst Biol Med. 2017 Jul;9(4). doi: 10.1002/wsbm.1382. Epub 2017 Feb 21.
Abstract
Metazoan species maintain oxygen homeostasis through the activity of hypoxia-inducible factors, which are transcriptional activators that regulate the expression of hundreds of genes to match O supply and demand. Here, we review the involvement of hypoxia-inducible factors in the molecular physiology and pathophysiology of cellular O sensing, O delivery, O utilization, and systemic O sensing. WIREs Syst Biol Med 2017, 9:e1382. doi: 10.1002/wsbm.1382 For further resources related to this article, please visit the WIREs website.
摘要
后生动物物种通过缺氧诱导因子的活性维持氧稳态，缺氧诱导因子是一种转录激活因子，可调节数百种基因的表达，以匹配氧气的供需。在这里，我们综述了缺氧诱导因子在细胞氧感知、氧输送、氧利用和全身氧感知的分子生理学和病理生理学中的作用。《WIREs系统生物学与医学》2017年，9:e1382。doi:10.1002/wsbm.1382 有关本文的更多资源，请访问WIREs网站。
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