Lalani Rohan, Misra Ambikanandan, Amrutiya Jitendra, Patel Hinal, Bhatt Priyanka, Patel Vivek
Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Kalabhavan Campus, Vadodara - 390001, Gujarat. India.
Department of Pharmaceutics, Faculty of Pharmacy, Kalabhavan Campus, The Maharaja Sayajirao University of Baroda, Vadodara. India.
Curr Drug Metab. 2017;18(5):426-436. doi: 10.2174/1389200218666170222151217.
Protein and peptides in biological system form an important part of innate immune system and are being explored for potential use in various diseases as therapeutics. Importance of proteins and peptides as a new class of antimicrobial agents has boosted research in the field of biotechnology as potential alternative to antibiotic agents.
Protein and peptides antimicrobial as a therapeutic class are structurally diverse and exhibit potent activity against microbes by various mechanisms. However, they present formidable challenge in formulation due to requirement of specific spatial configuration for their activity and stability. Thus, encapsulation of these therapeutics in various nano-systems may sustain activity along with improvement in stability.
The article highlights the need for antimicrobial peptides in dermal infections along with discussion of mechanism of their action. It highlights challenges faced for dermal delivery and research carried out for their successful delivery using nano-systems.
It is widely realized that these novel classes of therapeutic agents have tremendous market potential to emerge as an alternative to conventional antibiotic agents for combating issue of multidrug resistant microbial species. Research in their delivery aspects by use of current advances made in delivery systems through use of nanoconstructs offers much needed area for exploration and achieving success.
As there is an urgent need for coming up with new therapeutic agents for encompassing the increased burden of microbial diseases in human population as well as their delivery challenges, research in field will give the much-needed strategic advantage against pathogenic organisms.
生物系统中的蛋白质和肽是先天免疫系统的重要组成部分，目前正在探索其在各种疾病治疗中的潜在用途。蛋白质和肽作为一类新型抗菌剂的重要性推动了生物技术领域的研究，有望成为抗生素的潜在替代品。
作为治疗药物的蛋白质和肽类抗菌剂在结构上具有多样性，并通过多种机制对微生物表现出强大的活性。然而，由于其活性和稳定性需要特定的空间构型，它们在制剂方面面临巨大挑战。因此，将这些治疗剂封装在各种纳米系统中可能会维持其活性并提高稳定性。
本文强调了抗菌肽在皮肤感染中的需求，并讨论了其作用机制。强调了皮肤给药面临的挑战以及为使用纳米系统成功给药所开展的研究。
人们普遍认识到，这些新型治疗剂作为传统抗生素的替代品，在应对多重耐药微生物物种问题方面具有巨大的市场潜力。利用纳米构建体在递送系统方面的最新进展对其递送方面进行研究，为探索和取得成功提供了急需的领域。
由于迫切需要开发新的治疗剂来应对人类微生物疾病负担的增加及其递送挑战，该领域的研究将为对抗病原生物提供急需的战略优势。
