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Anti-obesity effect of ethanolic extract from Cosmos caudatus Kunth leaf in lean rats fed a high fat diet.

作者信息

Rahman Hafeedza Abdul, Sahib Najla Gooda, Saari Nazamid, Abas Faridah, Ismail Amin, Mumtaz Muhammad Waseem, Hamid Azizah Abdul

机构信息

School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600, UKM Bangi, Selangor, Malaysia.

Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia.

出版信息

BMC Complement Altern Med. 2017 Feb 22;17(1):122. doi: 10.1186/s12906-017-1640-4.

DOI:10.1186/s12906-017-1640-4
PMID:28228098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5322639/
Abstract

BACKGROUND: Obesity is a major health concern both in developed and developing countries. The use of herbal medicines became the subject of interest for the management of obesity due to its natural origin, cost effectiveness and minimal side effects. The present study aimed at investigating anti-obesity potential of ethanolic extract from Cosmos caudatus Kunth leaf (EECCL). METHODS: In this study, the rats were randomly divided into six groups i.e., (1) Normal Diet (ND); (2) Normal Diet and 175 mg/kgBW of EECCL (ND + 175 mg/kgBW); (3) Normal Diet and 350 mg/kgBW of EECCL (ND + 350 mg/kgBW); (4) High Fat Diet (HFD); (5) High Fat Diet and 175 mg/kgBW of EECCL (HFD + 175 mg/kgBW); (6) High Fat Diet and 350 mg/kgBW of EECCL (HFD + 350 mg/kgBW). The anti-obesity potential was evaluated through analyses of changes in body weight, visceral fat weight, and blood biochemicals including total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), leptin, insulin, adiponectin, ghrelin and fecal fat content. In addition, metabolite profiling of EECCL was carried out using NMR spectroscopy. RESULTS: Rats receiving EECCL together with HFD showed significant (p < 0.05) reduction in body weight gain compared to rats receiving HFD only. At the end of study, the body weight gain of EECCL treated rats was not significantly (p > 0.05) different with those of ND rats. Other related obesity biomarkers including plasma lipid profiles, insulin, leptin, ghrelin and adiponectin levels also showed significant improvement (p < 0.05). Administration of EECCL caused significant (p < 0.05) increase in fecal fat excretion, which validates the hypothesis of lipase inhibition, an anti-obesity mechanism similar to standard drug of Orlistat. The H-NMR spectra of EECCL ascertained the presence of catechin, quercetin, rutin, kaempherol and chlorogenic acid in the extract. CONCLUSION: Conclusively, EECCL showed anti-obesity properties by inhibition of intestinal lipid absorption and modulation of adipocytes markers.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/27150c860f03/12906_2017_1640_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/af0626510ca9/12906_2017_1640_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/9f40ba440381/12906_2017_1640_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/f88503e34418/12906_2017_1640_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/e47aa07ae6a6/12906_2017_1640_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/0eec04fd5d0b/12906_2017_1640_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/d5309a193aae/12906_2017_1640_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/f2e88e3821dd/12906_2017_1640_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/5c24d4a1b9b2/12906_2017_1640_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/1d9314b2864f/12906_2017_1640_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/27150c860f03/12906_2017_1640_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/af0626510ca9/12906_2017_1640_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/9f40ba440381/12906_2017_1640_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/f88503e34418/12906_2017_1640_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/e47aa07ae6a6/12906_2017_1640_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/0eec04fd5d0b/12906_2017_1640_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/d5309a193aae/12906_2017_1640_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/f2e88e3821dd/12906_2017_1640_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/5c24d4a1b9b2/12906_2017_1640_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/1d9314b2864f/12906_2017_1640_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3908/5322639/27150c860f03/12906_2017_1640_Fig10_HTML.jpg

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本文引用的文献

[1]
Germinated brown rice ameliorates obesity in high-fat diet induced obese rats.

BMC Complement Altern Med. 2016-5-23

[2]
Lipid Lowering Effects of Hydroalcoholic Extract of Anethum graveolens L. and Dill Tablet in High Cholesterol Fed Hamsters.

Cholesterol. 2015

[3]
Eight Weeks of Cosmos caudatus (Ulam Raja) Supplementation Improves Glycemic Status in Patients with Type 2 Diabetes: A Randomized Controlled Trial.

Evid Based Complement Alternat Med. 2015

[4]
The inhibitory effects of quercetin on obesity and obesity-induced inflammation by regulation of MAPK signaling.

J Nutr Biochem. 2015-11

[5]
The anti-obesity effect of green tea polysaccharides, polyphenols and caffeine in rats fed with a high-fat diet.

Food Funct. 2015-1

[6]
Effect of garlic extract on some serum biochemical parameters and expression of npc1l1, abca1, abcg5 and abcg8 genes in the intestine of hypercholesterolemic mice.

Indian J Biochem Biophys. 2013-12

[7]
Roles of chlorogenic Acid on regulating glucose and lipids metabolism: a review.

Evid Based Complement Alternat Med. 2013-8-25

[8]
Cosmos caudatus as a potential source of polyphenolic compounds: optimisation of oven drying conditions and characterisation of its functional properties.

Molecules. 2013-8-29

[9]
The in vitro and in vivo effects of yerba mate (Ilex paraguariensis) extract on adipogenesis.

Food Chem. 2013-4-30

[10]
Antiobesity potential of ursolic acid stearoyl glucoside by inhibiting pancreatic lipase.

Eur J Pharmacol. 2013-3-13

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