Arboleya Silvia, Martinez-Camblor Pablo, Solís Gonzalo, Suárez Marta, Fernández Nuria, de Los Reyes-Gavilán Clara G, Gueimonde Miguel
Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (CSIC) Villaviciosa, Spain.
Geisel School of Medicine at Dartmouth, Dartmouth CollegeHanover (NH), USA; Universidad Autónoma de ChileSantiago, Chile.
Front Microbiol. 2017 Feb 8;8:183. doi: 10.3389/fmicb.2017.00183. eCollection 2017.
The involvement of the gut microbiota on weight-gain and its relationship with childhood undernutrition and growth has been reported. Thus, the gut microbiota constitutes a potential therapeutic target for preventing growth impairment. However, our knowledge in this area is limited. In this study we aimed at evaluating the relationship among early microbiota, growth, and development in preterm infants. To this end we assessed the levels of specific microorganisms by qPCR, and those of short chain fatty acids by mean of gas-chromatography, in feces from 63 preterm newborns and determined their weight-gain during the first months. The statistical analyses performed indicate an influence of the intestinal microbiota in weight-gain, with the levels of some microorganisms showing a significant association with the weight-gain of the infant. The levels of specific microbial groups during the first days of life were found to affect weight gain by the age of 1 month. Moreover, clustering of the infants on the basis of the microbiota composition at 1 month of age rendered groups which showed differences in weight z-scores. Our results suggest an association between the gut microbiota composition and weight-gain in preterm infants at early life and point out potential microbial targets for favoring growth and maturation in these infants.
已有报道称肠道微生物群与体重增加有关，以及其与儿童期营养不良和生长的关系。因此，肠道微生物群构成了预防生长发育障碍的一个潜在治疗靶点。然而，我们在这一领域的知识是有限的。在本研究中，我们旨在评估早产儿早期微生物群、生长和发育之间的关系。为此，我们通过qPCR评估了63名早产新生儿粪便中特定微生物的水平，并通过气相色谱法测定了短链脂肪酸的水平，并确定了他们在头几个月的体重增加情况。所进行的统计分析表明肠道微生物群对体重增加有影响，一些微生物的水平与婴儿的体重增加有显著关联。发现出生后几天内特定微生物群的水平会影响1月龄时的体重增加。此外，根据1月龄时的微生物群组成对婴儿进行聚类，形成了体重z评分存在差异的组。我们的结果表明，早期生命中早产儿的肠道微生物群组成与体重增加之间存在关联，并指出了有利于这些婴儿生长和成熟的潜在微生物靶点。
