Luef K P, Stelzer F, Wiesbrock F
Graz University of Technology, Institute for Chemistry and Technology of Materials, NAWI Graz, Stremayrgasse 9/V, 8010 Graz, Austria; Polymer Competence Center Leoben, Roseggerstrasse 12, 8700 Leoben, Austria.
Graz University of Technology, Institute for Chemistry and Technology of Materials, NAWI Graz, Stremayrgasse 9/V, 8010 Graz, Austria.
Chem Biochem Eng Q. 2015;29(2):287-297. doi: 10.15255/CABEQ.2014.2261.
This review summarizes the state-of-the-art knowledge of the usage of poly(hydroxy alkanoate)s in medical and sanitary applications. Depending on the monomers incorporated into the polymers and copolymers, this class of polymers exhibits a broad range of (thermo-)plastic properties, enabling their processing by, e.g., solution casting or melt extrusion. In this review, strategies for the polymer analogous modification of these materials and their surfaces are highlighted and correlated with the potential applications of the corresponding materials and blends. While the commercial availability of purified PHAs is addressed in brief, special focus is put on the (bio-)degradability of these polymers and ways to influence the degradation mechanism and/or the duration of degradation.
本综述总结了聚羟基脂肪酸酯在医疗和卫生应用方面的最新知识。根据聚合物和共聚物中所含的单体，这类聚合物表现出广泛的（热）塑性特性，使其能够通过例如溶液浇铸或熔融挤出等方法进行加工。在本综述中，重点介绍了对这些材料及其表面进行聚合物类似改性的策略，并将其与相应材料和共混物的潜在应用相关联。虽然简要讨论了纯化聚羟基脂肪酸酯的商业可得性，但特别关注这些聚合物的（生物）降解性以及影响降解机制和/或降解持续时间的方法。
