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本文引用的文献

1
Carbapenem-resistant and colistin-resistant Escherichia coli co-producing NDM-9 and MCR-1.同时产NDM-9和MCR-1的耐碳青霉烯类和耐黏菌素大肠杆菌
Lancet Infect Dis. 2016 Mar;16(3):288-9. doi: 10.1016/S1473-3099(16)00057-8. Epub 2016 Feb 1.
2
Emergence of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae.耐碳青霉烯类肠杆菌科细菌中mcr-1黏菌素耐药基因的出现。
Lancet Infect Dis. 2016 Mar;16(3):287-8. doi: 10.1016/S1473-3099(16)00056-6. Epub 2016 Feb 1.
3
Investigation of a plasmid genome database for colistin-resistance gene mcr-1.针对黏菌素耐药基因mcr-1的质粒基因组数据库研究。
Lancet Infect Dis. 2016 Mar;16(3):284-5. doi: 10.1016/S1473-3099(16)00008-6. Epub 2016 Jan 8.
4
Colistin resistance gene mcr-1 in extended-spectrum β-lactamase-producing and carbapenemase-producing Gram-negative bacteria in Germany.德国产超广谱β-内酰胺酶和碳青霉烯酶的革兰氏阴性菌中的黏菌素耐药基因mcr-1
Lancet Infect Dis. 2016 Mar;16(3):282-3. doi: 10.1016/S1473-3099(16)00009-8. Epub 2016 Jan 8.
5
Colistin resistance gene mcr-1 and pHNSHP45 plasmid in human isolates of Escherichia coli and Klebsiella pneumoniae.人源大肠杆菌和肺炎克雷伯菌分离株中的黏菌素耐药基因mcr-1和pHNSHP45质粒
Lancet Infect Dis. 2016 Mar;16(3):285-6. doi: 10.1016/S1473-3099(16)00010-4. Epub 2016 Jan 8.
6
Dissemination of the mcr-1 colistin resistance gene.mcr-1 黏菌素耐药基因的传播
Lancet Infect Dis. 2016 Feb;16(2):147-9. doi: 10.1016/S1473-3099(15)00541-1. Epub 2015 Dec 18.
7
Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study.中国动物和人类中出现的质粒介导的粘菌素耐药机制 MCR-1：微生物学和分子生物学研究。
Lancet Infect Dis. 2016 Feb;16(2):161-8. doi: 10.1016/S1473-3099(15)00424-7. Epub 2015 Nov 19.
8
IncA/C Plasmid Carrying bla(NDM-1), bla(CMY-16), and fosA3 in a Salmonella enterica Serovar Corvallis Strain Isolated from a Migratory Wild Bird in Germany.从德国一只迁徙野生鸟类中分离出的肠炎沙门氏菌科瓦利斯菌株中携带bla(NDM-1)、bla(CMY-16)和fosA3的IncA/C质粒
Antimicrob Agents Chemother. 2015 Oct;59(10):6597-600. doi: 10.1128/AAC.00944-15. Epub 2015 Jul 13.
9
Insertion Sequence IS26 Reorganizes Plasmids in Clinically Isolated Multidrug-Resistant Bacteria by Replicative Transposition.插入序列IS26通过复制性转座在临床分离的多重耐药细菌中重组质粒。
mBio. 2015 Jun 9;6(3):e00762. doi: 10.1128/mBio.00762-15.
10
Complete nucleotide sequence of a blaKPC-harboring IncI2 plasmid and its dissemination in New Jersey and New York hospitals.blaKPC 携带型 IncI2 质粒的完整核苷酸序列及其在新泽西州和纽约州医院的传播。
Antimicrob Agents Chemother. 2013 Oct;57(10):5019-25. doi: 10.1128/AAC.01397-13. Epub 2013 Jul 29.

在产NDM-9的阪崎克罗诺杆菌及来自同一动物的大肠杆菌中出现黏菌素耐药基因mcr-1

Emergence of Colistin Resistance Gene mcr-1 in Cronobacter sakazakii Producing NDM-9 and in Escherichia coli from the Same Animal.

作者信息

Liu Bao-Tao, Song Feng-Jing, Zou Ming, Hao Zhi-Hui, Shan Hu

机构信息

College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, China

Qingdao Academy of Agricultural Sciences, Qingdao, China.

出版信息

Antimicrob Agents Chemother. 2017 Jan 24;61(2). doi: 10.1128/AAC.01444-16. Print 2017 Feb.

DOI:10.1128/AAC.01444-16
PMID:27855074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5278688/
Abstract

We report the presence of mcr-1 in Escherichia coli and carbapenem-resistant Cronobacter sakazakii from the same diseased chicken. The mcr-1 gene linked with ISApl1 was located on two different IncI2 plasmids, including one multidrug plasmid in E. coli, whereas fosA3-bla was on an IncB/O plasmid in C. sakazakii The development of the fosA3-bla resistance region was mediated by IS26 The colocation of mcr-1 or bla with other resistance genes will accelerate the dissemination of the two genes.

摘要

我们报告了在同一只患病鸡的大肠杆菌和耐碳青霉烯类阪崎肠杆菌中存在mcr-1。与ISApl1相连的mcr-1基因位于两个不同的IncI2质粒上，其中一个是大肠杆菌中的多药质粒，而fosA3-bla位于阪崎肠杆菌的一个IncB/O质粒上。fosA3-bla耐药区域的形成是由IS26介导的。mcr-1或bla与其他耐药基因的共定位将加速这两个基因的传播。