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Identification of human papillomavirus type 16 E7 protein by monoclonal antibodies.

作者信息

Oltersdorf T, Seedorf K, Röwekamp W, Gissmann L

机构信息

Institut für Virusforschung, Deutsches, Krebsforschungszentrum, Heidelberg, F.R.G.

出版信息

J Gen Virol. 1987 Nov;68 ( Pt 11):2933-8. doi: 10.1099/0022-1317-68-11-2933.

DOI:10.1099/0022-1317-68-11-2933
PMID:2824670
Abstract

A number of human papillomavirus (HPV) type 16 proteins have recently been identified in human cervical carcinoma cell lines using polyclonal antisera against papillomavirus gene products expressed in Escherichia coli. E7 protein has been found to be the most abundant papillomavirus protein in these cells. Here we describe a panel of monoclonal antibodies recognizing a 15K Mr non-glycosylated cytoplasmic HPV-16 E7 protein. One of the antibodies cross-reacted with HPV-18 E7 protein.

摘要

相似文献

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Identification of human papillomavirus type 16 E7 protein by monoclonal antibodies.
J Gen Virol. 1987 Nov;68 ( Pt 11):2933-8. doi: 10.1099/0022-1317-68-11-2933.
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引用本文的文献

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Expression of human papilloma virus type 16 antigens, specific targeting as well as formation of virus-like particles by HSV-1 amplicon vectors.16型人乳头瘤病毒抗原的表达、单纯疱疹病毒1型扩增载体的特异性靶向以及病毒样颗粒的形成。
Virus Genes. 2008 Oct;37(2):131-43. doi: 10.1007/s11262-008-0247-8. Epub 2008 Jun 12.
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Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130.人乳头瘤病毒16 E7在转化过程中的核内定位以及E7与Rb家族成员p130的优先结合
Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6999-7004. doi: 10.1073/pnas.96.12.6999.
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Antibodies against linear and conformational epitopes of the human papillomavirus (HPV) type 16 E6 and E7 oncoproteins in sera of cervical cancer patients.
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Arch Virol. 1994;137(3-4):341-53. doi: 10.1007/BF01309480.
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A point mutational analysis of human papillomavirus type 16 E7 protein.人乳头瘤病毒16型E7蛋白的点突变分析
J Virol. 1989 Jun;63(6):2650-6. doi: 10.1128/JVI.63.6.2650-2656.1989.
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EMBO J. 1989 Feb;8(2):513-9. doi: 10.1002/j.1460-2075.1989.tb03405.x.
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EMBO J. 1988 Jun;7(6):1815-20. doi: 10.1002/j.1460-2075.1988.tb03013.x.
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