Miri Narges, Lehmann Joerg, Legge Kimberley, Vial Philip, Greer Peter B
School of Mathematical and Physical Sciences, The University of Newcastle, Newcastle, Australia.
Phys Med Biol. 2017 Jun 7;62(11):4293-4299. doi: 10.1088/1361-6560/aa63df. Epub 2017 Mar 1.
A virtual EPID standard phantom audit (VESPA) has been implemented for remote auditing in support of facility credentialing for clinical trials using IMRT and VMAT. VESPA is based on published methods and a clinically established IMRT QA procedure, here extended to multi-vendor equipment. Facilities are provided with comprehensive instructions and CT datasets to create treatment plans. They deliver the treatment directly to their EPID without any phantom or couch in the beam. In addition, they deliver a set of simple calibration fields per instructions. Collected EPID images are uploaded electronically. In the analysis, the dose is projected back into a virtual cylindrical phantom. 3D gamma analysis is performed. 2D dose planes and linear dose profiles are provided and can be considered when needed for clarification. In addition, using a virtual flat-phantom, 2D field-by-field or arc-by-arc gamma analyses are performed. Pilot facilities covering a range of planning and delivery systems have performed data acquisition and upload successfully. Advantages of VESPA are (1) fast turnaround mainly driven by the facility's capability of providing the requested EPID images, (2) the possibility for facilities performing the audit in parallel, as there is no need to wait for a phantom, (3) simple and efficient credentialing for international facilities, (4) a large set of data points, and (5) a reduced impact on resources and environment as there is no need to transport heavy phantoms or audit staff. Limitations of the current implementation of VESPA for trials credentialing are that it does not provide absolute dosimetry, therefore a Level I audit is still required, and that it relies on correctly delivered open calibration fields, which are used for system calibration. The implemented EPID based IMRT and VMAT audit system promises to dramatically improve credentialing efficiency for clinical trials and wider applications.
一种虚拟电子射野影像装置(EPID)标准体模审核(VESPA)已被用于远程审核,以支持使用调强放疗(IMRT)和容积调强弧形放疗(VMAT)的临床试验机构资质认证。VESPA基于已发表的方法和临床确立的IMRT质量保证程序,在此扩展至多厂商设备。为各机构提供了全面的指导说明和CT数据集以创建治疗计划。他们将治疗直接施用于其EPID,射野中不放置任何体模或治疗床。此外,他们按照说明施照一组简单的校准野。采集到的EPID图像通过电子方式上传。在分析过程中,剂量被回投到一个虚拟圆柱形体模中。进行三维伽马分析。提供二维剂量平面和线性剂量剖面,如有需要可用于澄清。此外,使用虚拟平板体模,逐野或逐弧进行二维伽马分析。涵盖一系列计划和施照系统的试点机构已成功进行了数据采集和上传。VESPA的优势在于:(1)周转速度快,主要得益于机构提供所需EPID图像的能力;(2)各机构可并行进行审核,因为无需等待体模;(3)为国际机构提供简单高效的资质认证;(4)大量的数据点;(5)对资源和环境的影响较小,因为无需运输沉重的体模或审核人员。目前用于试验资质认证的VESPA实施存在的局限性在于,它不提供绝对剂量测定,因此仍需要一级审核,并且它依赖于正确施照的开放校准野,该校准野用于系统校准。已实施的基于EPID的IMRT和VMAT审核系统有望显著提高临床试验的资质认证效率及更广泛的应用。