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在一项3D适形放疗全国性审计中的剂量学端到端测试。

Dosimetric end-to-end tests in a national audit of 3D conformal radiotherapy.

作者信息

Lehmann Joerg, Alves Andrew, Dunn Leon, Shaw Maddison, Kenny John, Keehan Stephanie, Supple Jeremy, Gibbons Francis, Manktelow Sophie, Oliver Chris, Kron Tomas, Williams Ivan, Lye Jessica

机构信息

Australian Clinical Dosimetry Service (ACDS), Australian Radiation Protection and National Safety Agency (ARPANSA), 619 Lower Plenty Road, Yallambie, VIC 3085, Australia.

Institute of Medical Physics, School of Physics A28, University of Sydney NSW 2006, Australia.

出版信息

Phys Imaging Radiat Oncol. 2018 Apr 24;6:5-11. doi: 10.1016/j.phro.2018.03.006. eCollection 2018 Apr.

Abstract

BACKGROUND AND PURPOSE

Independent dosimetry audits improve quality and safety of radiation therapy. This work reports on design and findings of a comprehensive 3D conformal radiotherapy (3D-CRT) Level III audit.

MATERIALS AND METHODS

The audit was conducted as onsite audit using an anthropomorphic thorax phantom in an end-to-end test by the Australian Clinical Dosimetry Service (ACDS). Absolute dose point measurements were performed with Farmer-type ionization chambers. The audited treatment plans included open and half blocked fields, wedges and lung inhomogeneities. Audit results were determined as Pass Optimal Level (deviations within 3.3%), Pass Action Level (greater than 3.3% but within 5%) and Out of Tolerance (beyond 5%), as well as Reported Not Scored (RNS). The audit has been performed between July 2012 and January 2018 on 94 occasions, covering approximately 90% of all Australian facilities.

RESULTS

The audit pass rate was 87% (53% optimal). Fifty recommendations were given, mainly related to planning system commissioning. Dose overestimation behind low density inhomogeneities by the analytical anisotropic algorithm (AAA) was identified across facilities and found to extend to beam setups which resemble a typical breast cancer treatment beam placement. RNS measurements inside lung showed a variation in the opposite direction: AAA under-dosed a target beyond lung and over-dosed the lung upstream and downstream of the target. Results also highlighted shortcomings of some superposition and convolution algorithms in modelling large angle wedges.

CONCLUSIONS

This audit showed that 3D-CRT dosimetry audits remain relevant and can identify fundamental global and local problems that also affect advanced treatments.

摘要

背景与目的

独立剂量学审核可提高放射治疗的质量与安全性。本文报告了一项全面的三维适形放疗(3D-CRT)三级审核的设计与结果。

材料与方法

澳大利亚临床剂量测定服务机构(ACDS)通过使用人体胸部模型进行端到端测试,以现场审核的方式开展此次审核。采用 Farmer 型电离室进行绝对剂量点测量。审核的治疗计划包括开放野和半挡铅野、楔形板以及肺部不均匀性情况。审核结果分为通过最佳水平(偏差在 3.3%以内)、通过行动水平(大于 3.3%但在 5%以内)和超出公差(超过 5%),以及报告未计分(RNS)。此次审核在 2012 年 7 月至 2018 年 1 月期间进行了 94 次,覆盖了澳大利亚约 90%的机构。

结果

审核通过率为 87%(53%为最佳水平)。共给出了 50 条建议,主要与计划系统调试有关。各机构均发现分析各向异性算法(AAA)在低密度不均匀性区域后方存在剂量高估现象,且这种现象延伸至类似于典型乳腺癌治疗束放置的射束设置情况。肺部内部的 RNS 测量结果显示出相反方向的差异:AAA 在肺部以外的靶区剂量计算偏低,而在靶区上游和下游的肺部剂量计算偏高。结果还凸显了一些叠加和卷积算法在模拟大角度楔形板时的不足。

结论

此次审核表明,3D-CRT 剂量学审核仍然具有重要意义,能够识别影响先进治疗的基本全局和局部问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c54e/7807562/386b12995b57/gr1.jpg

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