Helal Nada A, Eassa Heba A, Amer Ahmed M, Eltokhy Mohamed A, Edafiogho Ivan, Nounou Mohamed I
Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt.
Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy for Girls, Al Azhar University, Cairo, 11651, Egypt.
Recent Pat Drug Deliv Formul. 2019;13(2):105-156. doi: 10.2174/1872211313666190503112040.
Traditional nutraceuticals and cosmeceuticals hold pragmatic nature with respect to their definitions, claims, purposes and marketing strategies. Their definitions are not well established worldwide. They also have different regulatory definitions and registration regulatory processes in different parts of the world. Global prevalence of nutraceuticals and cosmeceuticals is noticeably high with large market share with minimal regulation compared to traditional drugs. The global market is flooded with nutraceuticals and cosmeceuticals claiming to be of natural origin and sold with a therapeutic claim by major online retail stores such as Amazon and eBay. Apart from the traditional formulations, many manufacturers and researchers use novel formulation technologies in nutraceutical and cosmeceutical formulations for different reasons and objectives. Manufacturers tend to differentiate their products with novel formulations to increase market appeal and sales. On the other hand, researchers use novel strategies to enhance nutraceuticals and cosmeceuticals activity and safety. The objective of this review is to assess the current patents and research adopting novel formulation strategies in nutraceuticals and cosmeceuticals. Patents and research papers investigating nutraceutical and cosmeceutical novel formulations were surveyed for the past 15 years. Various nanosystems and advanced biotechnology systems have been introduced to improve the therapeutic efficacy, safety and market appeal of nutraceuticals and cosmeceuticals, including liposomes, polymeric micelles, quantum dots, nanoparticles, and dendrimers. This review provides an overview of nutraceuticals and cosmeceuticals current technologies, highlighting their pros, cons, misconceptions, regulatory definitions and market. This review also aims in separating the science from fiction in the nutraceuticals and cosmeceuticals development, research and marketing.
传统的营养保健品和药妆品在其定义、宣称、目的和营销策略方面具有务实的性质。它们的定义在全球范围内尚未明确确立。在世界不同地区，它们也有不同的监管定义和注册监管程序。与传统药物相比，营养保健品和药妆品在全球的普及率显著较高，市场份额大且监管极少。全球市场充斥着宣称天然来源并带有治疗功效宣称的营养保健品和药妆品，在亚马逊和易趣等主要在线零售商店销售。除了传统配方，许多制造商和研究人员出于不同原因和目标，在营养保健品和药妆品配方中使用新型配方技术。制造商倾向于用新型配方来区分他们的产品，以增加市场吸引力和销量。另一方面，研究人员采用新策略来提高营养保健品和药妆品的活性和安全性。本综述的目的是评估当前在营养保健品和药妆品中采用新型配方策略的专利和研究。对过去15年中研究营养保健品和药妆品新型配方的专利和研究论文进行了调查。已经引入了各种纳米系统和先进生物技术系统来提高营养保健品和药妆品的治疗效果、安全性和市场吸引力，包括脂质体、聚合物胶束、量子点、纳米颗粒和树枝状大分子。本综述概述了营养保健品和药妆品的当前技术，突出了它们的优点、缺点、误解、监管定义和市场情况。本综述还旨在在营养保健品和药妆品的开发、研究和营销中区分科学与虚构。
