School of Life Science, Anhui University, Hefei 230039, P. R. China.
Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230039, P. R. China.
Chem Commun (Camb). 2017 Mar 16;53(23):3303-3306. doi: 10.1039/c6cc09470h.
We present a two-photon (2P, 800 nm) PDT cyclometalated Iridium(iii) complex (Ir-Es) that targets the intracellular nucleus. The complex is capable of migrating sequentially from the nucleus to mitochondria and inducing dual-damage under light exposure. This study suggests that with minor modification of the terminal moieties of complexes, their final intracellular destinations and PDT efficiency can be significantly impacted.
我们提出了一种双光子（2P，800nm）光敏剂环金属铱（III）配合物（Ir-Es），它靶向细胞内的细胞核。该配合物能够在光暴露下依次从细胞核迁移到线粒体并诱导双重损伤。本研究表明，通过对配合物末端基团进行微小修饰，可以显著影响其最终的细胞内定位和 PDT 效率。
