den Blaauwen Tanneke, Hamoen Leendert W, Levin Petra Anne
Swammerdam Institute for Life Sciences, University of Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Department of Biology, Washington University in St. Louis, St. Louis, MO 63130, USA.
Curr Opin Microbiol. 2017 Apr;36:85-94. doi: 10.1016/j.mib.2017.01.007. Epub 2017 Mar 6.
The identification of the FtsZ ring by Bi and Lutkenhaus in 1991 was a defining moment for the field of bacterial cell division. Not only did the presence of the FtsZ ring provide fodder for the next 25 years of research, the application of a then cutting-edge approach-immunogold labeling of bacterial cells-inspired other investigators to apply similarly state-of-the-art technologies in their own work. These efforts have led to important advances in our understanding of the factors underlying assembly and maintenance of the division machinery. At the same time, significant questions about the mechanisms coordinating division with cell growth, DNA replication, and chromosome segregation remain. This review addresses the most prominent of these questions, setting the stage for the next 25 years.
1991年，Bi和Lutkenhaus对FtsZ环的鉴定是细菌细胞分裂领域的一个决定性时刻。FtsZ环的存在不仅为接下来25年的研究提供了素材，当时一种前沿方法——细菌细胞的免疫金标记——的应用还启发了其他研究人员在自己的工作中应用类似的先进技术。这些努力推动了我们在理解分裂机器组装和维持背后因素方面取得重要进展。与此同时，关于协调细胞分裂与细胞生长、DNA复制和染色体分离机制的重大问题依然存在。本综述探讨了其中最突出的问题，为未来25年的研究奠定基础。
