Zhang Meilin, Gao Yuxia, Tian Liqiang, Zheng Li, Wang Xuan, Liu Weiqiao, Zhang Yuwen, Huang Guowei
Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, PR China.
Department of Cardiology, General Hospital of Tianjin Medical University, Tianjin, PR China.
Clin Chim Acta. 2017 May;468:152-158. doi: 10.1016/j.cca.2017.02.022. Epub 2017 Mar 1.
The association of vitamin D status and inflammation prediabetes mellitus (PreDM) individuals has not been investigated. We investigated the association of serum 25-hydroxyvitamin D (25(OH) D) with adipokines and inflammatory markers in persons with PreDM.
In this cross-sectional study, we stratified 418 nondiabetic subjects as having PreDM or normal fasting glucose (NFG), and divided PreDM or NFG subjects into vitamin D sufficient, vitamin D insufficient and vitamin D deficient subgroups. 25(OH) D concentrations were determined by HPLC. Serum tumor necrosis factor-α (TNF-α), interleiukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP), adiponectin, leptin and resistin were measured by ELISA.
In the PreDM group, compared with those in the vitamin D sufficient subgroup, vitamin D insufficient subgroup and vitamin D deficient subgroup had higher concentrations of hs-CRP and leptin (P<0.05). In the PreDM-deficient or PreDM-insufficient subgroup, mean hs-CRP and leptin concentration was higher than in the PreDM-sufficient, NFG-deficient, NFG-insufficient and NFG-sufficient subgroups (P<0.05). Serum 25(OH) D concentrations were inversely associated with hs-CRP and leptin concentrations after adjusted the BMI only in the PreDM group (P<0.05). At the multivariate analysis, hs-CRP and leptin were the major determinant of 25(OH) D concentration (β=-0.174 and β=-0.171, respectively).
25(OH) D status in PreDM individuals was inversely correlated with concentrations of hs-CRP and leptin, suggesting their involvement in the inflammation response between vitamin D status and PreDM.
维生素D状态与糖尿病前期（PreDM）个体炎症之间的关联尚未得到研究。我们调查了PreDM患者血清25-羟维生素D（25(OH)D）与脂肪因子及炎症标志物之间的关联。
在这项横断面研究中，我们将418名非糖尿病受试者分为PreDM或空腹血糖正常（NFG）组，并将PreDM或NFG受试者分为维生素D充足、维生素D不足和维生素D缺乏亚组。采用高效液相色谱法测定25(OH)D浓度。采用酶联免疫吸附测定法检测血清肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和高敏C反应蛋白（hs-CRP）、脂联素、瘦素和抵抗素。
在PreDM组中，与维生素D充足亚组相比，维生素D不足亚组和维生素D缺乏亚组的hs-CRP和瘦素浓度更高（P<0.05）。在PreDM缺乏或PreDM不足亚组中，hs-CRP和瘦素的平均浓度高于PreDM充足、NFG缺乏、NFG不足和NFG充足亚组（P<0.05）。仅在PreDM组中，调整体重指数后，血清25(OH)D浓度与hs-CRP和瘦素浓度呈负相关（P<0.05）。在多变量分析中，hs-CRP和瘦素是25(OH)D浓度的主要决定因素（β分别为-0.174和-0.171）。
PreDM个体的25(OH)D状态与hs-CRP和瘦素浓度呈负相关，提示它们参与了维生素D状态与PreDM之间的炎症反应。
