唐氏综合征患儿唾液分泌型IgA浓度与龋齿情况
Salivary secretory IgA concentration and dental caries in children with Down syndrome.
作者信息
Hashizume Lina N, Schwertner Carolina, Moreira Maurício José Santos, Coitinho Adriana Simon, Faccini Lavinia Schuler
机构信息
Department of Preventive and Social Dentistry, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Department of Microbiology, Immunology and Parasitology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
出版信息
Spec Care Dentist. 2017 May;37(3):115-119. doi: 10.1111/scd.12222. Epub 2017 Mar 6.
PURPOSE
To evaluate the relationship between salivary secretory immunoglobulin A (sIgA) concentration and dental caries in children with Down syndrome (DS) and compare it with findings in non-DS children.
METHODS
The sample comprised 61 DS children and 52 non-DS children, aged 6 to 14 years. Caries experience, plaque index (PI), and gingival bleeding index (GBI) were recorded. Saliva samples were collected from all children. Total salivary sIgA concentrations were determined using an enzymatic assay method.
RESULTS
Caries experience in primary and permanent dentitions were similar in DS and non-DS children. However, PI and GBI values were significantly lower in DS compared to non-DS children. DS children had higher salivary sIgA concentrations compared to non-DS children. No difference in sIgA concentration was observed between children with and without caries experience in either group.
CONCLUSIONS
DS children have higher salivary sIgA concentrations than non-DS children. However, this finding did not correlate with caries experience in the study population.
目的
评估唐氏综合征（DS）患儿唾液分泌型免疫球蛋白A（sIgA）浓度与龋齿之间的关系，并将其与非DS患儿的研究结果进行比较。
方法
样本包括61名6至14岁的DS患儿和52名非DS患儿。记录龋病经历、菌斑指数（PI）和牙龈出血指数（GBI）。收集所有患儿的唾液样本。采用酶法测定唾液中sIgA的总浓度。
结果
DS患儿和非DS患儿乳牙和恒牙的龋病经历相似。然而，与非DS患儿相比，DS患儿的PI和GBI值显著更低。与非DS患儿相比，DS患儿的唾液sIgA浓度更高。两组中有龋病经历和无龋病经历的患儿之间，sIgA浓度均未观察到差异。
结论
DS患儿的唾液sIgA浓度高于非DS患儿。然而，这一发现与研究人群中的龋病经历无关。
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