龋齿和唾液 sIgA 与吸烟的关系。

Association of dental caries and salivary sIgA with tobacco smoking.

机构信息

Department of Periodontology, School of Dentistry, Ahvaz Jondishapour University of Medical Sciences, Ahvaz, Iran.

出版信息

Aust Dent J. 2013 Jun;58(2):219-23. doi: 10.1111/adj.12059. Epub 2013 May 5.

DOI:10.1111/adj.12059

PMID:23713643

Abstract

BACKGROUND

Salivary secretory IgA (sIgA) is said to play an important role in the immune response against dental caries. This study aimed to determine the salivary sIgA levels in healthy smokers and non-smokers, and its correlation with dental caries.

METHODS

A total of 70 healthy subjects were selected and classified into four groups according to dental caries and tobacco smoking habits: smoking with caries (Group 1, n = 15); smoking without caries (Group 2, n = 15); non-smoking with caries (Group 3, n = 15); and non-smoking without caries (Group 4, n = 25). Salivary sIgA was measured using ELISA. The fissure and proximal caries were examined clinically and radiographically. Caries status was determined according to the decay surface index.

RESULTS

Smokers showed a higher number of caries and the lowest concentration of sIgA. The highest levels of sIgA were observed in non-smoking and caries-free subjects compared to caries-active smokers (123.2 ± 19.9 vs. 13.3 ± 4.1 μg/ml respectively, p < 0.001). Also, the mean level of sIgA in Group 4 was significantly higher than Group 3 (p = 0.009). More importantly, higher and significant levels of sIgA were found in Group 3 versus Group 1 (p < 0.0001) and Group 2 (p = 0.0004).

CONCLUSIONS

Our findings indicate that low concentrations of salivary sIgA are correlated with a higher prevalence of dental caries in smokers.

摘要

背景

唾液分泌型免疫球蛋白 A（sIgA）被认为在抗龋齿免疫反应中发挥重要作用。本研究旨在确定健康吸烟者和非吸烟者的唾液 sIgA 水平及其与龋齿的相关性。

方法

共选择 70 名健康受试者，根据龋齿和吸烟习惯将其分为四组：有龋齿的吸烟者（第 1 组，n = 15）；无龋齿的吸烟者（第 2 组，n = 15）；有龋齿的非吸烟者（第 3 组，n = 15）；无龋齿的非吸烟者（第 4 组，n = 25）。采用 ELISA 法检测唾液 sIgA。临床和影像学检查窝沟和邻面龋。根据龋面指数确定龋病状况。

结果

吸烟者的龋齿数较多，sIgA 浓度最低。与活跃吸烟者相比，非吸烟者和无龋齿者的 sIgA 水平最高（123.2 ± 19.9 与 13.3 ± 4.1 μg/ml 相比，p < 0.001）。此外，第 4 组的 sIgA 均值明显高于第 3 组（p = 0.009）。更重要的是，第 3 组的 sIgA 水平明显高于第 1 组（p < 0.0001）和第 2 组（p = 0.0004）。