对多发性硬化症患者、对照者及其他神经系统疾病患者的血清学研究：抗人嗜T淋巴细胞病毒I型、II型、III型抗体

Serologic studies of MS patients, controls, and patients with other neurologic diseases: antibodies to HTLV-I, II, III.

作者信息

Madden D L, Mundon F K, Tzan N R, Fuccillo D A, Dalakas M C, Calabrese V, Elizan T S, Sever J L

机构信息

National Institute of Neurological and Communicative Disorders and Stroke, MD 20892.

出版信息

Neurology. 1988 Jan;38(1):81-4. doi: 10.1212/wnl.38.1.81.

DOI:10.1212/wnl.38.1.81

PMID:2827054

Abstract

We have studied the frequency of human retrovirus antibody (HTLV-I, II, III) in the serum and CSF of patients with MS, matched controls, and patients with optic neuritis, idiopathic and postencephalitic Parkinson's disease, neuropathies, polymyositis, ALS, and postpoliomyelitis. Except for the postpoliomyelitis samples, all samples were collected prior to 1980. Contrary to a previous published report, no significant levels of antibody to HTLV-I, II, or III were found in the MS patients or controls. No retrovirus antibody was detected in patients with the other neurologic diseases.

摘要

我们研究了多发性硬化症患者、匹配的对照组以及视神经炎、特发性和脑炎后帕金森病、神经病、多发性肌炎、肌萎缩侧索硬化症和脊髓灰质炎后患者的血清和脑脊液中人类逆转录病毒抗体（HTLV-I、II、III）的频率。除脊髓灰质炎后样本外，所有样本均在1980年之前采集。与之前发表的报告相反，在多发性硬化症患者或对照组中未发现HTLV-I、II或III抗体的显著水平。在其他神经系统疾病患者中未检测到逆转录病毒抗体。