Trindade Leda Maria Delmondes Freitas, Menezes Lania Barreto de Oliveira, de Souza Neta Adozina Marques, Leite Rolemberg Paulo Candido, Souza Lais Dantas, Barreto Ikaro Daniel de Carvalho, Meurer Luise
Department of Medicine, Tiradentes University, Aracaju 49032-490, Brazil.
Biometrics and Applied Statistics - PPGBEA - UFRPE, Aracaju 49160-000, Brazil.
Gastroenterology Res. 2017 Feb;10(1):33-41. doi: 10.14740/gr785w. Epub 2017 Feb 21.
() infection affects about 50% of the world population and its association with environmental factors and host properties is involved in gastric carcinogenesis. The study aimed to estimate the prevalence of in samples of gastric mucosa biopsies, correlate the presence of the bacteria in the sample with the variables age, sex and origin, to identify the types of lesions found in patients with , and to evaluate the association of the lesions with the region of the gastric mucosa.
A cross-sectional, retrospective study was carried out in Aracaju, Sergipe, Brazil, from January 2013 to December 2015. A total of 45,206 gastric mucosal biopsies were obtained from patients submitted to upper gastrointestinal endoscopy. Of the reports evaluated, 12,909 met the inclusion criteria since they presented the patient's demographic data as well as the histopathological characteristics of gastric mucosal regions and positivity for . Data were analyzed by IBM SPSS Statistic 20 and subjected to descriptive analyses (categorical variables) and inferential (Pearson's Qui-square and linear association tests) and multiple correspondence analyses. Significance level adopted 5%.
Of the total of 12,909 (28.6%) reports evaluated, 67% (8,647) came from urban areas and 64.5% (8,320) were female. The mean age (standard deviation (SD)) was 43 years, ranging from 8 to 100 years, prevailing between 21 and 60 years. Among the types of gastric mucosa analyzed, 95.5% (12,322) were of the antral mucosa. The absence of glandular atrophy, the mild infection intensity for , the absence of metaplasia, the presence of foveolar hyperplasia and lymphoid follicles were statistically significant (P < 0.001) in this region. In the fundic region, the evidence of fibrinoleucocytic crust and lymphoid follicles was significant (P < 0.001). There was no evidence of associated ulcerated lesions or significant relationship with intestinal metaplasia in the antral mucosa, whereas the fundic mucosa had a strong association with lymphoid follicles. The prevalence of active infection in this study was 30.93%.
Detection rate of and its association with acute and chronic inflammation should be taken into account. The antral region has shown higher incidence and the presence of was strongly associated with foveolar hyperplasia and lymphoid follicles.
（）感染影响着全球约50%的人口，其与环境因素和宿主特性的关联参与了胃癌的发生。本研究旨在估计胃黏膜活检样本中（）的感染率，将样本中细菌的存在与年龄、性别和来源等变量相关联，识别（）患者中发现的病变类型，并评估病变与胃黏膜区域的关联。
2013年1月至2015年12月在巴西塞尔希培州阿拉卡茹进行了一项横断面回顾性研究。共从接受上消化道内镜检查的患者中获取了45206份胃黏膜活检样本。在评估的报告中，12909份符合纳入标准，因为它们呈现了患者的人口统计学数据以及胃黏膜区域的组织病理学特征和（）检测阳性结果。数据通过IBM SPSS Statistic 20进行分析，并进行描述性分析（分类变量）、推断性分析（Pearson卡方检验和线性关联检验）以及多重对应分析。采用的显著性水平为5%。
在总共12909份（28.6%）评估报告中，67%（8647份）来自城市地区，64.5%（8320份）为女性。平均年龄（标准差（SD））为43岁，范围从8岁到100岁，以21岁至60岁为主。在所分析的胃黏膜类型中，95.5%（12322份）为胃窦黏膜。该区域无腺萎缩、（）感染强度轻度、无化生、有小凹增生和淋巴滤泡在统计学上具有显著意义（P < 0.001）。在胃底区域，纤维蛋白白细胞性结痂和淋巴滤泡的证据具有显著意义（P < 0.001）。胃窦黏膜未发现相关溃疡病变或与肠化生有显著关系，而胃底黏膜与淋巴滤泡有很强的关联。本研究中活动性（）感染的患病率为30.93%。
应考虑（）的检出率及其与急慢性炎症的关联。胃窦区域显示出较高的发病率，且（）的存在与小凹增生和淋巴滤泡密切相关。
