术前中性粒细胞与淋巴细胞比值对睾丸生殖细胞肿瘤预后的预测价值。
Predictive value of preoperative neutrophil-to-lymphocyte ratio on the prognosis of germ cell testicular tumors.
作者信息
Bolat Deniz, Aydoğdu Özgü, Polat Salih, Yarımoğlu Serkan, Bozkurt İbrahim Halil, Yonguç Tarık, Şen Volkan
机构信息
Clinic of Urology, Bozyaka Training and Research Hospital, İzmir, Turkey.
出版信息
Turk J Urol. 2017 Mar;43(1):55-61. doi: 10.5152/tud.2016.38924. Epub 2016 Dec 14.
OBJECTIVE
We investigated the prognostic value of preoperative neutrophil-to-lymphocyte ratio (NLR) on germ cell testicular tumors (GCT).
MATERIAL AND METHODS
The data of 53 patients who underwent inguinal orchiectomy were analyzed retrospectively. NLR was calculated from the preoperative complete blood cell counts. Receiver operating characteristic (ROC) analysis was performed to find the threshold values for NLR. Correlations between cancer-specific survival (CSS) and progression-free survival (PFS) and NLR were evaluated.
RESULTS
The mean follow-up time was 23.55±18.06 months. The mean level of NLR was 3.08±1.81. Optimal threshold values of NLR was calculated as 3.55 for PFS (area under curve, AUC: 0.55) and 3.0 for CSS (AUC: 0.66). For patients with a NLR of <3.55 and NLR of ≥3.55, mean times-to-progression were 55.71 months (95% CI, 51.27-60.14) and 51.95 months (95% CI, 38.02-65.87, p=0.152), respectively. As well as, for patients with a NLR of <3.0 and NLR of ≥3.0, mean times-to-cancer specific death were 54.72 months (95% CI, 49.05-60.38) and 49.43 months (95% CI, 37.64-61.22, p=0.119), respectively.
CONCLUSION
Preoperative NLR is not a useful tool to predict the prognosis of patients with GCT.
目的
我们研究了术前中性粒细胞与淋巴细胞比值（NLR）对睾丸生殖细胞肿瘤（GCT）的预后价值。
材料与方法
回顾性分析53例行腹股沟睾丸切除术患者的数据。根据术前全血细胞计数计算NLR。进行受试者操作特征（ROC）分析以确定NLR的阈值。评估癌症特异性生存（CSS）、无进展生存（PFS）与NLR之间的相关性。
结果
平均随访时间为23.55±18.06个月。NLR的平均水平为3.08±1.81。计算得出PFS的NLR最佳阈值为3.55（曲线下面积，AUC：0.55），CSS的为3.0（AUC：0.66）。对于NLR<3.55和NLR≥3.55的患者，平均进展时间分别为55.71个月（95%CI，51.27 - 60.14）和51.95个月（95%CI，38.02 - 65.87，p = 0.152）。同样，对于NLR<3.0和NLR≥3.0的患者，平均癌症特异性死亡时间分别为54.72个月（95%CI，49.05 - 60.38）和49.43个月（95%CI，37.64 - 61.22，p = 0.119）。
结论
术前NLR并非预测GCT患者预后的有用工具。
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