发育过程中血红蛋白氧合的超声引导光谱光声成像
Ultrasound-guided spectral photoacoustic imaging of hemoglobin oxygenation during development.
作者信息
Bayer Carolyn L, Wlodarczyk Bogdan J, Finnell Richard H, Emelianov Stanislav Y
机构信息
Department of Biomedical Engineering, The University of Texas at Austin, 1 University Station, Austin, TX 78712, USA; Currently with the Department of Biomedical Engineering, Tulane University, 500 Lindy Boggs Center, New Orleans, LA 70118, USA.
Dell Pediatric Research Institute, Department of Nutritional Sciences, The University of Texas at Austin, 1400 Barbara Jordan Blvd, Austin, TX 78723, USA.
出版信息
Biomed Opt Express. 2017 Jan 10;8(2):757-763. doi: 10.1364/BOE.8.000757. eCollection 2017 Feb 1.
Abstract
Few technologies are capable of imaging function during development. In this study, we have implemented spectral photoacoustic imaging to estimate tissue oxygenation longitudinally in pregnant mice. We used the spectral photoacoustic signal to estimate hemoglobin oxygen saturation within intact, mouse concepti from developmental day (E) 8.5 to E16.5-a first step towards functional imaging of the maternal-fetal environment. Future work will apply these methods to compare longitudinal functional changes during normal vs abnormal development of embryos, fetuses, and placentas.
摘要
很少有技术能够在发育过程中对功能进行成像。在本研究中，我们实施了光谱光声成像，以纵向估计怀孕小鼠的组织氧合情况。我们使用光谱光声信号来估计发育第（E）8.5天至E16.5天完整小鼠胚胎内的血红蛋白氧饱和度，这是朝着母胎环境功能成像迈出的第一步。未来的工作将应用这些方法来比较胚胎、胎儿和胎盘正常与异常发育过程中的纵向功能变化。
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