• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Perilipin polymorphisms are risk factors for the development of obesity in adolescents? A case-control study.perilipin基因多态性是青少年肥胖发生的危险因素？一项病例对照研究。
Lipids Health Dis. 2017 Mar 9;16(1):52. doi: 10.1186/s12944-017-0440-7.
2
Adipokine Gene Single-Nucleotide Polymorphisms in Portuguese Obese Adolescents: Associations with Plasma Concentrations of Adiponectin, Resistin, IL-6, IL-1β, and TNF-α.葡萄牙肥胖青少年脂肪因子基因单核苷酸多态性：与脂联素、抵抗素、白细胞介素-6、白细胞介素-1β和肿瘤坏死因子-α血浆浓度的关联
Child Obes. 2016 Aug;12(4):300-13. doi: 10.1089/chi.2015.0235. Epub 2016 May 9.
3
ADIPOQ -11377C>G Polymorphism Increases the Risk of Adipokine Abnormalities and Child Obesity Regardless of Dietary Intake.ADIPOQ基因-11377C>G多态性增加脂肪因子异常和儿童肥胖风险，与饮食摄入无关。
J Pediatr Gastroenterol Nutr. 2016 Jan;62(1):122-9. doi: 10.1097/MPG.0000000000000900.
4
Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents.脂联素（PLIN）基因变异对肥胖儿童和青少年代谢综合征风险及体重减轻的影响。
J Clin Endocrinol Metab. 2008 Dec;93(12):4933-40. doi: 10.1210/jc.2008-0947. Epub 2008 Sep 23.
5
Perilipin gene 1237 T > C polymorphism is not associated with obesity risk in northern Chinese Han adults. perilipin 基因 1237T > C 多态性与中国北方汉族成年人肥胖风险无关。
Biomed Environ Sci. 2009 Oct;22(5):442-7. doi: 10.1016/S0895-3988(10)60023-2.
6
Polymorphisms in perilipin gene (PLIN) are not associated with obesity and weight variation in people with high risk of type 2 diabetes.perilipin基因（PLIN）多态性与2型糖尿病高危人群的肥胖和体重变化无关。
Exp Clin Endocrinol Diabetes. 2008 Sep;116 Suppl 1:S56-8. doi: 10.1055/s-2008-1081493. Epub 2008 Sep 5.
7
Genetic association of adipokine and UCP2 polymorphism with recurrent miscarriage among non-obese women.脂联素和 UCP2 多态性与非肥胖女性复发性流产的遗传关联。
Reprod Biomed Online. 2012 Nov;25(5):527-35. doi: 10.1016/j.rbmo.2012.07.006. Epub 2012 Jul 20.
8
Common variations in perilipin gene, central obesity, and risk of type 2 diabetes in US women.美国女性中脂联素基因的常见变异、中心性肥胖与2型糖尿病风险
Obesity (Silver Spring). 2008 May;16(5):1061-5. doi: 10.1038/oby.2008.26. Epub 2008 Mar 6.
9
Sex-Dependent Mediation of Leptin in the Association of Perilipin Polymorphisms with BMI and Plasma Lipid Levels in Children.性别依赖性中介作用：瘦素在儿童载脂蛋白脂蛋白多态性与 BMI 和血浆脂质水平关联中的作用。
Nutrients. 2022 Jul 26;14(15):3072. doi: 10.3390/nu14153072.
10
Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population.人类围脂滴蛋白基因（PLIN）的基因内连锁不平衡结构以及多民族亚洲人群中与肥胖风险增加相关的单倍型
J Mol Med (Berl). 2005 Jun;83(6):448-56. doi: 10.1007/s00109-004-0630-4. Epub 2005 Mar 16.

引用本文的文献

1
Exploring the Interplay of Genetics and Nutrition in the Rising Epidemic of Obesity and Metabolic Diseases.探讨遗传学与营养在肥胖症和代谢性疾病日益流行中的相互作用。
Nutrients. 2024 Oct 21;16(20):3562. doi: 10.3390/nu16203562.
2
Association of Umbilical Cord Perilipin 2 Levels with Neonatal Anthropometric Measurements in Infants of Diabetic Mothers.糖尿病母亲婴儿脐带周脂联素2水平与新生儿人体测量指标的关联
Children (Basel). 2024 Jun 25;11(7):771. doi: 10.3390/children11070771.
3
Genetic Association Between Polycystic Ovary Syndrome and the rs662799 and rs894160 Metabolic Variants in the Western Saudi Population: A Case-Control Study.沙特西部人群中多囊卵巢综合征与rs662799和rs894160代谢变异之间的遗传关联：一项病例对照研究
Biomark Insights. 2024 Jun 16;19:11772719241258585. doi: 10.1177/11772719241258585. eCollection 2024.
4
The Genetic Basis of Childhood Obesity: A Systematic Review.儿童肥胖的遗传学基础：系统评价。
Nutrients. 2023 Mar 15;15(6):1416. doi: 10.3390/nu15061416.
5
Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study.2型脱碘酶Thr92Ala多态性与日本儿童肥胖症的关联：一项病例对照研究
Children (Basel). 2022 Sep 20;9(10):1421. doi: 10.3390/children9101421.
6
Sex-Dependent Mediation of Leptin in the Association of Perilipin Polymorphisms with BMI and Plasma Lipid Levels in Children.性别依赖性中介作用：瘦素在儿童载脂蛋白脂蛋白多态性与 BMI 和血浆脂质水平关联中的作用。
Nutrients. 2022 Jul 26;14(15):3072. doi: 10.3390/nu14153072.

本文引用的文献

1
Ghrelin function in human obesity and type 2 diabetes: a concise review.生长激素释放肽在人类肥胖和 2 型糖尿病中的作用：简要综述。
Obes Rev. 2017 Feb;18(2):140-148. doi: 10.1111/obr.12474. Epub 2016 Nov 29.
2
Heart lipid droplets and lipid droplet-binding proteins: Biochemistry, physiology, and pathology.心脏脂滴与脂滴结合蛋白：生物化学、生理学及病理学
Exp Cell Res. 2016 Jan 15;340(2):198-204. doi: 10.1016/j.yexcr.2015.10.031. Epub 2015 Oct 30.
3
Pathophysiology of lipid droplet proteins in liver diseases.肝脏疾病中脂滴蛋白的病理生理学
Exp Cell Res. 2016 Jan 15;340(2):187-92. doi: 10.1016/j.yexcr.2015.10.021. Epub 2015 Oct 26.
4
Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting.溶质载体家族 7a3a 的基因缺失导致禁食状态下斑马鱼的肝脂肪变性。
Hepatology. 2014 Dec;60(6):1929-41. doi: 10.1002/hep.27356. Epub 2014 Nov 4.
5
Update on perilipin polymorphisms and obesity.关于 perilipin 多态性与肥胖的最新研究进展。
Nutr Rev. 2012 Oct;70(10):611-21. doi: 10.1111/j.1753-4887.2012.00515.x.
6
Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity.国际肥胖工作组（IOTF）制定的消瘦、超重和肥胖的扩展身体质量指数临界值。
Pediatr Obes. 2012 Aug;7(4):284-94. doi: 10.1111/j.2047-6310.2012.00064.x. Epub 2012 Jun 19.
7
Hormones and cytokines in childhood obesity.儿童肥胖中的激素和细胞因子。
Indian Pediatr. 2010 Oct;47(10):829-39. doi: 10.1007/s13312-010-0142-y.
8
Association of lifestyle factors, polymorphisms in adiponectin, perilipin and hormone sensitive lipase, and clinical markers in Japanese males.日本男性生活方式因素、脂联素、围脂滴蛋白和激素敏感性脂肪酶基因多态性与临床指标的关联
J Nutr Sci Vitaminol (Tokyo). 2010;56(2):123-31. doi: 10.3177/jnsv.56.123.
9
Relationship between perilipin gene polymorphisms and body weight and body composition during weight loss and weight maintenance.减肥和体重维持期间脂滴包被蛋白基因多态性与体重及身体成分的关系。
Physiol Behav. 2009 Mar 23;96(4-5):723-8. doi: 10.1016/j.physbeh.2009.01.011.
10
Association of serum leptin and adiponectin with obesity in asthmatics.哮喘患者血清瘦素和脂联素与肥胖的关系
J Asthma. 2009 Feb;46(1):59-63. doi: 10.1080/02770900802444203.

perilipin基因多态性是青少年肥胖发生的危险因素？一项病例对照研究。

Perilipin polymorphisms are risk factors for the development of obesity in adolescents? A case-control study.

作者信息

Tokgöz Yavuz, Işık Ishak Abdurrahman, Akbari Soheil, Kume Tuncay, Sayın Oya, Erdal Esra, Arslan Nur

机构信息

Department of Pediatric Gastroenterology, Hepatology and Nutrition, Dokuz Eylul University Faculty of Medicine, 35330, Inciraltı-Izmir, Turkey.

Department of Medical Biology, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.

出版信息

Lipids Health Dis. 2017 Mar 9;16(1):52. doi: 10.1186/s12944-017-0440-7.

DOI:10.1186/s12944-017-0440-7
PMID:28274232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5343409/
Abstract

BACKGROUND

The variations in perilipin gene (PLIN) were previously associated with obesity. We examined the association of polymorphisms at the PLIN locus in adolescents with obesity and their connection with serum adipokines.

METHODS

A total of 308 children (206 obese, 66.8% and 102 healthy control, 33.2%) between the ages of 10-18 years were included into the study. PLIN gene analysis [PLIN 1, PLIN 4, PLIN 6, PLIN 5'UTR-1234 C > G and PLIN 10171 A/T] were studied by Real Time-PCR. Serum leptin, adiponectin, resistin and ghrelin levels were studied by ELISA method in both groups and their link with perilipin polymorphisms were analyzed.

RESULTS

Serum leptin level was found significantly high in obese adolescents. Other adipokine levels were similar in both groups. The incidence of PLIN 1, PLIN 4, PLIN 5'UTR-1234 C > G and PLIN 10171 A/T minor and major alleles was similar in both groups. PLIN 6 T/T allele was determined significantly high in obese adolescents compared to that of control group. No correlation was detected between perilipin polymorphism and serum levels of adipokines.

CONCLUSION

The PLIN 6 polymorphism of the perilipin gene may influence the risk of the obesity during adolescence.

TRIAL REGISTRATION

Retrospectively registered.

摘要

背景

此前研究发现脂联素基因（PLIN）的变异与肥胖有关。我们研究了青少年肥胖患者中PLIN基因座多态性的关联及其与血清脂肪因子的关系。

方法

本研究共纳入308名10至18岁的儿童（206名肥胖儿童，占66.8%；102名健康对照儿童，占33.2%）。通过实时定量聚合酶链反应（Real Time-PCR）对PLIN基因[PLIN 1、PLIN 4、PLIN 6、PLIN 5'非翻译区-1234 C>G和PLIN 10171 A/T]进行分析。采用酶联免疫吸附测定法（ELISA）检测两组儿童血清瘦素、脂联素、抵抗素和胃饥饿素水平，并分析其与脂联素基因多态性的关系。

结果

肥胖青少年的血清瘦素水平显著升高。两组的其他脂肪因子水平相似。两组中PLIN 1、PLIN 4、PLIN 5'非翻译区-1234 C>G和PLIN 10171 A/T等位基因的次要和主要等位基因发生率相似。与对照组相比，肥胖青少年中PLIN 6 T/T等位基因的比例显著升高。未检测到脂联素基因多态性与血清脂肪因子水平之间的相关性。

结论

脂联素基因的PLIN 6多态性可能影响青少年肥胖的风险。

试验注册

回顾性注册。